The figure below summarizes the results of an experiment evaluating the role of Ku80 gene DNA repair. The Ku80 Knock Out mice were generated by genetically deleting the Ku80 gene and the effects of ionizing radiation on lifespan were evaluated. Briefly explain why Ku80 deletion has the observed effects. What form of DNA damage is causing the reduced lifespan and which repair mechanism appears to be responsible for repair of these lesion in normal mice?
The figure below summarizes the results of an experiment evaluating the role of Ku80 gene DNA repair. The Ku80 Knock Out mice were generated by genetically deleting the Ku80 gene and the effects of ionizing radiation on lifespan were evaluated. Briefly explain why Ku80 deletion has the observed effects. What form of DNA damage is causing the reduced lifespan and which repair mechanism appears to be responsible for repair of these lesion in normal mice?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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The figure below summarizes the results of an experiment evaluating the role of Ku80 gene DNA repair. The Ku80 Knock Out mice were generated by genetically deleting the Ku80 gene and the effects of ionizing radiation on lifespan were evaluated. Briefly explain why Ku80 deletion has the observed effects. What form of DNA damage is causing the reduced lifespan and which repair mechanism appears to be responsible for repair of these lesion in normal mice?
Transcribed Image Text:A.
B.
Percent Survival
irrad.
WT
100
90
80
70-
60
50
40
30
20
10
0
0
5
10
Days
irrad.
Ku80+
15
20
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