DNA supercoiling, which occurs when coiling tension is generated ahead of the replication fork, is relieved by DNA gyrase. Supercoiling may also be involved in transcription regulation. Researchers discovered that enhancers operating over a long distance (2500 bp) are dependent on DNA supercoiling, while enhancers operating over shorter distances (110 bp) are not so dependent [Liu et al. (2001). Proc. Natl. Acad. Sci. USA 98:14,883–14,888]. Using a diagram, suggest a way in which supercoiling may positively influence enhancer activity over long distances.
DNA supercoiling, which occurs when coiling tension is generated ahead of the replication fork, is relieved by DNA gyrase. Supercoiling may also be involved in transcription regulation. Researchers discovered that enhancers operating over a long distance (2500 bp) are dependent on DNA supercoiling, while enhancers operating over shorter distances (110 bp) are not so dependent [Liu et al. (2001). Proc. Natl. Acad. Sci. USA 98:14,883–14,888]. Using a diagram, suggest a way in which supercoiling may positively influence enhancer activity over long distances.
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DNA supercoiling, which occurs when coiling tension is generated
ahead of the replication fork, is relieved by DNA gyrase.
Supercoiling may also be involved in transcription regulation.
Researchers discovered that enhancers operating over a
long distance (2500 bp) are dependent on DNA supercoiling,
while enhancers operating over shorter distances (110 bp) are
not so dependent [Liu et al. (2001). Proc. Natl. Acad. Sci. USA
98:14,883–14,888]. Using a diagram, suggest a way in which
supercoiling may positively influence enhancer activity over long
distances.
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