The data below illustrates the role of MutS, MutH and Dam in DNA repair. Strains of E coli that are wild-type (FX-11) or with inactive forms of MutS or MutH as well as strains without dam methylase. Explain the function of MutS and MutH and why their deletion enhance the mutation rate of E coli. Why does deletion of the dam gene increase the mutation rate further?

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Chapter1: The Human Body: An Orientation
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The data below illustrates the role of MutS, MutH and Dam in DNA repair. Strains of E coli that are wild-type (FX-11) or with inactive forms of MutS or MutH as well as strains without dam methylase. Explain the function of MutS and MutH and why their deletion enhance the mutation rate of E coli. Why does deletion of the dam gene increase the mutation rate further?

Spontancous mutation frequencies (x 106)
0.6
0.5
0.4
0.3
0.2
0.1
EX-11
**
Dam
MutH
*
Muts
Dam & MutH Dam & Muts
Transcribed Image Text:Spontancous mutation frequencies (x 106) 0.6 0.5 0.4 0.3 0.2 0.1 EX-11 ** Dam MutH * Muts Dam & MutH Dam & Muts
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