O a base substitution in an intron 5' splice site O a frameshift in an exon O a missense in an exon O a base substitution in an enhancer region
O a base substitution in an intron 5' splice site O a frameshift in an exon O a missense in an exon O a base substitution in an enhancer region
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter9: Gene Expression And Gene Regulation
Section: Chapter Questions
Problem 10QP: The pre-mRNA transcript and protein made by several mutant genes were examined. The results are...
Question
![Nonfunctional HexA protein is responsible for the autosomal recessive
disease Tay Sachs. A patient with Tay Sachs produces a normal amount of
full length but non-functional HexA protein. Of the choices below, what is the
most likely type of mutation responsible for the disease?
O a base substitution in an intron 5' splice site.
a frameshift in an exon
O a missense in an exon
O a base substitution in an enhancer region](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Faefc02fc-f1ae-4f90-a486-edd86b942252%2F02997277-755e-48a8-ab74-2465f3b9395b%2Fnbn66zl_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Nonfunctional HexA protein is responsible for the autosomal recessive
disease Tay Sachs. A patient with Tay Sachs produces a normal amount of
full length but non-functional HexA protein. Of the choices below, what is the
most likely type of mutation responsible for the disease?
O a base substitution in an intron 5' splice site.
a frameshift in an exon
O a missense in an exon
O a base substitution in an enhancer region
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