In cancerous cells, telomeres are substantially longer then telomeres found in non-cancerous cells.  As a result a number of scientists who study cancer treatment have become interested in telomerase.  Why might telomerase be a good target for anticancer therapies?  How might anticancer therapies targeting telomerase work (no need to design an experiment, just brainstorm how the therapy might impact telomeres of cancer cells)?

Q: Which of these pairs of clinical applications of DNA repair mechanisms is not accurate? Group of…

A: To correct the DNA damage within cells, the cell uses various cellular repair mechanisms called DNA…

Q: Telomerase is not active in most human cells. Some cancer biologists have suggested that activation…

A: Telomere is a repetitive nucleotide sequence added at each end of the chromosome. It acts as a…

Q: The figure below summarizes the results of an experiment evaluating the role of Ku80 gene DNA…

A: The gene knockout is performed for the detection of the role of a specific gene. The elimination of…

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A: Cystic fibrosis is an inherited life threatening disorder that causes severe damages to lungs,…

Q: Consider the microarray in Figure 20.12. If a sample from normal tissue is labeled with a green…

A: Introduction  Gene are the key component of genetic material which control almost all the cellular…

Q: Describe the process of somatic cell nuclear transfer and how it is used to create cloned cells.…

A: As per the guidelines, the first question is answered. Somatic nuclear cell transfer (SCNT) is a…

Q: The goal of most gene therapies is to insert a healthy copy of a gene into the genome.  Besides…

A: Genome editing:It is also known as gene editing or genome engineering. It is a type of genetic…

Q: In chemotherapy, what are the mechanism of action of cisplatin and alkylating agents.  Why are these…

A: Chemotherapy is a medication treatment that employs the use of potent chemicals to kill rapidly…

Q: The introduction of genes into plants is a common practice that has generated not only a host of…

A: No, the tumor-inducing genes are removed from the plasmid, eliminating the threat of tumor…

Q: Could quantitative PCR, which uses a DNA-binding dye, to show how many copies of the target DNA…

A: Quantitative reverse transcription PCR (RT-qPCR) is used when the starting material is RNA. In this…

Q: In the treatment of cancer, the basis for many types of chemotherapyand radiation therapy is that…

A: The tumor is irregular growth of tissue. It is the first stage of tumor development. The…

Q: (b) How many forms can naturally occurring DNA exist in? Explain how these forms are characterized.…

A: DNA  Deoxyribonucleic acid  Genetic material in many species Has ds(double stranded) structure…

Q: It was suspected that the cause of the infertility seen in a patient was due to undiagnosed non-…

A: The question is asking us to determine the number of fragments that would be visible on an agarose…

Q: In a clinical context, doctors are evaluating a therapy for a new patient (say patient B) that they…

A: In the setting of assessing treatment for a modern patient (patient B) who may develop comparable…

Q: The student sets up the assay and analyzes the presence of the oncogene in normal and tumor issue…

A: •Cancer cells have more genetic changes than normal cells. •Genetic changes that lead to cancer…

Q: If telomeres are normally shortened after each round of replication in somatic cells (see Chapter…

A: Cloning is the creation of identical biological entities for therapeutic and reproduction. It is…

Q: 5 5 S 6 5 5 5 6 U 6 U 6 5:14 PM | 0.2KB/s HHHHH R R U RUUR ARU AP AP R U U R R AP R R R AP…

A: Transcription is the process of formation of mRNA from DNA template strands by an enzyme called RNA…

Q: The polymerase chain reaction can only be used to amplify genes that have been cloned and sequenced.…

A: The polymerase chain reaction was originally developed by the American biochemist Kary Mullis. The…

Q: A graduate student who has not taken BIOL 519 thinks they have discovered a new oncogene that could…

A: Cancer develops as a result of damaged genes. These damaged genes are frequently caused by…

Q: In 1994, telomerase activity was discovered in human cancer cell lines. Although telomerase is not…

A: The expectation of this survey is to depict what is known and obscure about telomerase in…

Q: Dr. Serena Velazquez lands a coveted post-doc position at Johns Hopkins following completion of her…

A: The study of cancer therapeutics is an important area of research in the field of oncology. With the…

Q: How does the sigma factor of E. coli RNA polymerase bind to promoters? Question 14 options: a…

A: Sigma factors direct the binding of RNA polymerase to promoters. It places the enzyme in a position…

Q: Generally, one single mutation is enough to cause cancer. [Select] Cancer-causing mutations cause…

A: When the genes that control cell division are disrupted, cancer cells are produced. Carcinogenesis…

Q: Which of the following types of physical mutagens produces thymine dimmer mutations? A- gamma rays…

A: Given:       Physical mutagens produces thymine dimmer mutations.

Q: Site directed mutagenesis is used to: 1.determine the critical base per sequences in a Genome 2.…

A: DNA consists of double strands of sequentially arranged nucleotides. The nucleotide sequence present…

Q: You are trying to study the effects of Drug A on the expression of Gene X in a tumor sample (lane…

A: Reverse transcription enzyme chain reaction (RT-PCR) may be a variation of normal PCR that involves…

Q: The ability to selectively modify the genome in the mouse has revolutionized mouse genetics. Outline…

A: Molecular biology's applications include the development of new protein products, illness prevention…

Q: The carboxy terminus of the p53 protein acts as an allosteric regulator of sequence-specific DNA…

A: General structure of p53 protein

Q: Retinoblastoma is an extremely rare cancer of the retina in the eye. The disease mainly affects…

A: The investigation into retinoblastoma, a uncommon eye cancer fundamentally influencing children,…

Q: please answer these questions for this image What is the source of the DNA? What is the target?…

A: The objective of the question is to understand the process of genetic engineering, specifically the…

Q: I am a Physician Scientist and have a patient that presents with colorectal cancer. I decide to…

A: Given the scenario you've described, where a novel SNP leads to a premature stop codon in a gene…

Q: You have a patient slated to undergo somatic cell gene therapy to alleviate a cystic fibrosis…

A: Answer: Cystic fibrosis is the result of homozygous recessive mutations in the CFTR gene.

Q: ou were tasked to develop two types of vaccines: a DNA vaccine and a protein subunit vaccine. For…

A: Recombinant DNA Vaccine : Live attenuated vaccine : These are the vaccines where whole bacteria or…

Cancer Therapy