telomerase inhibitors to treat hepatocellular carcinoma. They test their drugs on the purified telomerase from both humans and mice and find they are very potent inhibitors of enzyme activity. The drugs also inhibit growth of HEPG2 cells which are an immortalized human liver cell line. As a final study before commencing human trials, they test the effect of the drugs on formation of liver tumors in mice treated with a potent hepatocarcinogen. Unfortunately they see no effect of these drugs on development of liver tumors in mice. Explain the fundamental mistake the researchers made in this experiment. What defect might you expect these mice to have if their embryos were treated with these drugs early in development?

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