Answered: Which of these pairs of clinical…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question

Which of these pairs of clinical applications of DNA repair mechanisms is not accurate?

Group of answer choices

Loss of BRCA2 correlates to decreased sensitivity of Breast cancer cells to DNA-damaging agents

Loss of BRCA1 expression correlates to Increased sensitivity of Ovarian cancer cells to Cisplatin

BRCA1 expression is a marker of survival in Non-Small cell Lung Cancer Patients

Defective Homologous Repair correlates to increased sensitivity to Alkylating Agents

Expert Solution

Step 1: Introduction:

To correct the DNA damage within cells, the cell uses various cellular repair mechanisms called DNA repair mechanisms. These mechanisms are of several types, including base excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end joining repair. Base excision repair is usually used to correct single base damage, single-strand breaks, or DNA lesions. Nucleotide excision repair is used to repair DNA lesions resulting from UV radiation and chemicals. Mismatch repair is used to repair the errors produced during DNA replication.. Homologous recombination and non-homologous end joining repair the double-strand breaks present in DNA by joining the two breaks of the double strands.

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