Which of the following statements are correct about cancer drug resistance (select all that apply)?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Which of the following statements are correct about cancer drug resistance (select all that apply)?

  A.

It is inevitable that a tumor will eventually become resistant to a given cancer drug

  B.

Solid tumors often develop drugs resistance through upregulating expression of drug transporters.

  C.

If the probability of develop resistance to drug A is 1/10 and for Drug B is also 1/10, then the probility of developing resistance to Drug A and B combination therapy is 1/20.

  D.

Effective multidrug protocols use 3 drugs that all target the same mechanisms of killing cancer cell

 

  E.

Drug resistance ofter develops when p53 is inactivated

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