Are genome and karyotype instabilities consequences
or causes of cancer?
Genome ad karyotype instabilities really leads to cancer.Lets have a detailed discussion:
Genome instability refers to a range of DNA alterations, from point mutations and deletions and insertions to chromosomal rearrangements and whole chromosome numerical changes, which irreversibly change the information content of the genome.
Genomes are unstable because of the continuous induction of damage to DNA, mostly from endogenous sources. It should be noted that DNA damage is not the same as DNA mutations. DNA damage involves physical alterations in nucleic acid structure, e.g., breaks, depurination, depyrimidination, crosslinks, modified bases, while mutations arise as errors during repair or replication of DNA damage and sometimes spontaneously. Mutations are additions, deletions or substitutions of bits of genetic code, including chromosomal aberrations, transpositions and copy number variation. Together they are part of the phenomenon of genome instability.
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