What is meant by ‘degree of differentiation’ in tumour biology and how this can be determined? Why is it important to know this information
What is meant by ‘degree of differentiation’ in tumour biology and how this can be determined? Why is it important to know this information?
A tumor is a mass of tissue that is produced by an irregular cell buildup. The cells in our body usually mature, die, and are replaced by new cells. Some factors disrupt this mechanism of cells and give rise to tumors. Tumor cells expand, but the body does not require them, and unlike ordinary old cells, they do not die. As this mechanism goes on, and more and more cells are added to the mass, the tumor begins to expand.
In cancer, differentiation relates to how mature the cancer cells are in a tumor (developed). Differentiated tumor cells mimic human cells and appear to develop and propagate more steadily than undifferentiated or poorly differentiated tumor cells, uncontrollably developing and lacking normal cells' structure and function.
A biopsy is the best way to detect cancer in certain cases accurately. In the laboratory, under a microscope, doctors look at cell cultures. Regular cells of equal sizes and organized organization appear identical. With different sizes and without obvious structure, cancer cells appear less orderly. Diagnosing cancer also offers the greatest hope for treatment in the early stages. The diagnosis and treatment of a tumor become easy if the degree of differentiation is known.
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