Malaria, one of the most pervasive and destructive of all infectious diseases, is caused by protozoan parasites of the genus Plasmodium, which are transmitted from person to person by mosquitoes. Plasmodium parasites are able to evade the host immune system by constantly altering the expression of their var genes, which encode Plasmodium surface antigens (L. H. Freitas-Junior et al. 2005. Cell 121:25–36). Individual var genes are expressed when chromatin structure is disrupted by chemical changes in histone proteins. What type of chemical changes in the histone proteins might be responsible for these changes in gene expression?
Malaria, one of the most pervasive and destructive of all infectious diseases, is caused by protozoan parasites of the genus Plasmodium, which are transmitted from person to person by mosquitoes. Plasmodium parasites are able to evade the host immune system by constantly altering the expression of their var genes, which encode Plasmodium surface antigens (L. H. Freitas-Junior et al. 2005. Cell 121:25–36). Individual var genes are expressed when chromatin structure is disrupted by chemical changes in histone proteins. What type of chemical changes in the histone proteins might be responsible for these changes in gene expression?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Malaria, one of the most pervasive and destructive of all infectious
diseases, is caused by protozoan
which are transmitted from person to person by mosquitoes.
Plasmodium parasites are able to evade the host immune system by
constantly altering the expression of their var genes, which encode
Plasmodium surface antigens (L. H. Freitas-Junior et al. 2005. Cell
121:25–36). Individual var genes are expressed when chromatin
structure is disrupted by chemical changes in histone proteins. What
type of chemical changes in the histone proteins might be responsible
for these changes in gene expression?
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