Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 geneand is associated with the early onset of cancers and the development of multiple malignant lesionsof diverse tissue origins?

Answered: Which genetic cancer predisposition…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

See similar textbooks

Related questions

Question

Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene
and is associated with the early onset of cancers and the development of multiple malignant lesions
of diverse tissue origins?

Expert Solution

Step 1

P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the genome because it prevents genome mutation and maintains stability. The main functions of these proteins are to arrest the cell cycle in case of any DNA damage, activate the DNA repair mechanism, if DNA damage is irreparable then it initiates apoptosis and in response to the shortened telomere it also causes senescence.

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions