Explain whether a cancercausing mutation in a tumorsuppressor gene, such as p53,
is more likely to be a recessive or
a dominant mutation.
Tumor suppressor gene regulates a cell during the cell division and replication. If cells grows without any control then they leads to in cancer. When a tumor suppressor gene, such as p53, got mutated then they loss their function or show reduced activity. In addition with the other genetic mutations it allows the abnormal growth of the cell. The loss of function of these genes is more significant in the development of cancer in humans.
The tumor suppressor genes usually follow the two-hit hypothesis, which says that both the alleles that code for a specific protein must be affected before an effect is manifested. The cancer-causing mutation in a tumor suppressor gene, such as p53, is usually recessive, because if only one allele for this gene is get damaged, then the other allele can still produce the enough correct protein to retain the appropriate function of the protein.
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