Researchers have identified a gene in humans that (when mutant)causes severe dwarfism and mental impairment. This disorder isinherited in an autosomal recessive manner, and the mutant alleleis known to be a loss-of-function mutation. The same gene hasbeen found in mice, although a mutant version of the gene has notbeen discovered in mice. To develop drugs and an effective therapyto treat this disorder in humans, it would be experimentallyuseful to have a mouse model. In other words, it would be desirableto develop a strain of mice that carry the mutant allele in thehomozygous condition. Experimentally, how would you developsuch a strain?

Q: What phenotypes do you think a homozygous tra1hsn animal with a loss of function Egl-1 mutation…

A: The phenotype is the physical appearance or observable trait of an individual genotype. The…

Q: Prader-Willi syndrome and Angelman syndrome

A: Genetic disorders: The inherited medical condition or disorder caused by a DNA abnormality is known…

Q: Both ADA-SCID and type I diabetes are diseases based on lack of a particular protein. Why has the…

A: ADA means Adenosine deaminase deficiency and SCID is severe combined immunodeficiency.  ADA-SCID is…

Q: When a particular mutagen identified by the Ames testis injected into mice, it causes the appearance…

A: Cancer is considered to be a disease that has abnormal cell growth that can invasive. The cancerous…

Q: Some molecules found in foods are known to be capable ofdriving DNA methylation or DNA…

A: Epigenetics means external modifications to a gene’s DNA which outcomes in alterations in gene…

Q: How many of the mutations listed below would lead to excessive cell growth when the cell was either…

A: Excessive growth occurs when a cell continuously divides and when there is no cell cycle arrest. Myc…

Q: Induced mutations result from ________.     exposure to a hazard such as a chemical exposure to a…

A: Muttations are defined as the mechanism in which the genes present in the DNA changes or alters due…

Q: When 1 million cells of a culture of haploid yeastcarrying a met− auxotrophic mutation were plated…

A: Mutations can cause a novel mutant allele to revert to wild type in a process called reverse…

Q: Which of the following experimental observations suggest that adisease has a genetic basis?A. The…

A: Gene is a functional unit of heredity. A gene is a sequence of nucleotides in genome that codes for…

Q: Although most cases of cystic fibrosis are inherited in an autosomal recessive manner, it is…

A: Inheritance is the process of transmitting the traits from parent to offspring. Traits of an…

Q: If the effects of mutations 1 +3 is an eye size intermediate between wild type and mutation 1 alone,…

A: DNA or deoxyribonucleic acid is a polymer of deoxyribonucleotides connected together via…

Q: Explain Null (amorphic) and leaky mutations (hypomorphic), hypermorphic and neomorphic mutations

A: Mutations (changes in a gene sequence) can result in mutant alleles that no longer produce the same…

Q: In E. coli, a variety of mutator strains have been identified inwhich the spontaneous rate of…

A: Mutations are the alterations or the changes that occur in the DNA. Mutations are variations in…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.