How does the activity of human p53 get regulated through the interaction of the transactivation domains with its corresponding macromolecules when the cell is under stress vs unstressed conditions?
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
How does the activity of human p53 get regulated through the interaction of the transactivation domains with its corresponding macromolecules when the cell is under stress vs unstressed conditions?
based on this articles
- Primary paper:
Lee, C. W., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2010). Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein. Biochemistry, 49(46), 9964–9971. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982890/#SD1
- https://www.rcsb.org/structure/2L14 PDB file for TAD domain
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