Many viruses that infect eukaryotic cells express genes that alterthe regulation of host gene expression to promote viral replication.For example, herpes simplex virus-1 (HSV-1) expresses aprotein called ICP0, which is necessary for successful viral infectionand replication within the host. Lutz et al. (2017. Viruses9: 210) showed that ICP0 can act as a ubiquitin ligase and targetthe redundant transcriptional repressors ZEB1 and ZEB2,which leads to upregulation of the miR-183 cluster (a set of threemiRNAs transcribed from the same locus). How may ICP0 expression in a host cell lead to upregulationof the miR-183 cluster?
Many viruses that infect eukaryotic cells express genes that alter
the regulation of host gene expression to promote viral replication.
For example, herpes simplex virus-1 (HSV-1) expresses a
protein called ICP0, which is necessary for successful viral infection
and replication within the host. Lutz et al. (2017. Viruses
9: 210) showed that ICP0 can act as a ubiquitin ligase and target
the redundant transcriptional repressors ZEB1 and ZEB2,
which leads to upregulation of the miR-183 cluster (a set of three
miRNAs transcribed from the same locus).
How may ICP0 expression in a host cell lead to upregulation
of the miR-183 cluster?
Many viruses that infect eukaryotic cells express genes that encode proteins that alter the regulation of host gene expression. These proteins often promote viral replication by upregulating specific genes.
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