Using molecular cloning, a hybrid receptoer is produced that consists of the extracellular domain of the B-adrenergicreceptor (B-AR) and the transmembrane and intracellular domains of the EGF receptor (EGFR).Question:What is the stoichiometric ratio of epinephrine to the hybrid receptor (B-AR-EGFR)?1:1O 1:4O 1:22:1O O O

The activation of several G protein-coupled receptors (GPCRs) mimics the stimulation of the…

Answered: Question: What is the stoichiometric…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The EC50 of an agonist for a GPCR is almost always (greater than, equal to, or less than) the KD of the same agonist at the same GPCR. Why?
Atropine (I) and Ipratropium bromide (II) are both muscarinic acetylcholine receptor antagonists. Common side effects of atropine (1) include dizziness, blurred vision, and sedation. With Ipratropium bromide (II) these side effects are much less common. Given the two structures below, what might be the reason for the different side-effect profile of the two drugs? Br HO HO
Why might the GluR-B mutation prevent calcium from moving through the receptor?
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2+ Activation of 5-HT2A Increases cytosolic free Ca²+ Concentration ([Ca²+]) Via a Signaling cascade. At rest, neurons have a cytosolic Ca Concentration of 100nM. The ex- Tra cellular free calcium concentration is typically 1.2m M. Calculate the resting potential (at equilibrium) produced by the neuron as a result of the calcium ion concentration gradient. (Report your answer in mV ).
Arrange following the boxed information in sequence regarding the dissociation and reassociation of G proteins following the activation of a G protein coupled receptor. GTP-bound Ga, dissociates from B and y cuhunits Gas exchanges GTP for GDP Gas reassociates with By subunits and the rorentor reforms Binding of the ligand to a G-protein rounled recentor GTP-bound Gas binds and activates adenvlul rurlase GTP is hydrolyzed and GDP bound Gas suhunit dissoriates Conformational change Increased synthesis of CAMP from ATP
A GRK inhibitor would have what effect on GPCR inactivation in the presence of a GPCR agonist? (a) it would decrease it; (b) it would maintain the same rate of inactivation; (c) it would increase it.
From the Hill Plot below, the KD of the first binding event for the receptor-ligand system under study is: 10 8 6 4 2 0 -2 4 6 8 10 (0=1) 601 log -4- -6 -6 -4 -2 0 2
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#1B-arrestin is always active. #2 Lack of kinase domain in BARK #3 ß1-adrenergic membrane receptor lacking it's ligand-binding domain

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Question: What is the stoichiometric ratio of epinephrine to the hybrid receptor (B-AR-EGFR)? O 1:1 O 1:4 O 1:2 O 2:1