Using molecular cloning, a hybrid receptoer is produced that consists of the extracellular domain of the B-adrenergicreceptor (B-AR) and the transmembrane and intracellular domains of the EGF receptor (EGFR).Question:What is the stoichiometric ratio of epinephrine to the hybrid receptor (B-AR-EGFR)?1:1O 1:4O 1:22:1O O O

The activation of several G protein-coupled receptors (GPCRs) mimics the stimulation of the…

Answered: Question: What is the stoichiometric…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Item21 Item 21 Neurons have a _______ membrane potential of –70mV. In other words, this is their stable membrane potential under normal conditions. Fill in the blank Fill in the blank Item22 Item 22 When a skin wound is healing, cell contact on all sides is a strong stimulus for cell division. Group startsTrue or False Item23 Item 23 Which choice describes the activation steps of a G protein-coupled receptor properly (and in correct order)? Multiple Choice Ligand binds to receptor, G protein activated, effector protein activated, second messenger made available Ligand binds to receptor, second messenger activated, G protein turned on, protein kinase activated Protein kinase activated, ion channel opened, ions enter and activate second messenger, G protein turned on Ion channel opened, G protein activated, second messenger synthesized, phosphatase ends signal
The EC50 of an agonist for a GPCR is almost always (greater than, equal to, or less than) the KD of the same agonist at the same GPCR. Why?
alpha 1 adrenergic receptor causes vasoconstriction through activation of Gq protein explain the mechanism of action for this receptorb starting from the ligand binding step untill final effectoe is activated
How does 17 beta estradiol action differ from that of hormones that bind G-protein-coupled receptors?
Atropine (I) and Ipratropium bromide (II) are both muscarinic acetylcholine receptor antagonists. Common side effects of atropine (1) include dizziness, blurred vision, and sedation. With Ipratropium bromide (II) these side effects are much less common. Given the two structures below, what might be the reason for the different side-effect profile of the two drugs? Br HO HO
Why might the GluR-B mutation prevent calcium from moving through the receptor?
Do you expect worms with defects in unc-17 to become hyper-contracted and paralyzed by levamisole
In Chapter 3, the Kd of calmodulin EF hands for binding Ca2+ is given as 10−6 M. Many proteins have much higher affinities for their respective ligands. Why is the specific affinity of calmodulin important for Ca2+ signaling pro- cesses such as that initiated by production of IP3?
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Question 14 of 25 Which statements best describe serotonin? Select the correct response(s): 0 It is essential for control of muscular movement and sensation of pleasure. It is essential for gut motility and regulation of circadian rhythm. It is derived from the amino acid with the phenolic side chain. It is derived from the amino acid with the indole side chain. It triggers the body's response during emergency situation. It was proven to be directly related to clinical depression. It is derived from the amino acid with the imidazole side chain. It is derived from the amino acid with the benzyl side chain. 4
2+ Activation of 5-HT2A Increases cytosolic free Ca²+ Concentration ([Ca²+]) Via a Signaling cascade. At rest, neurons have a cytosolic Ca Concentration of 100nM. The ex- Tra cellular free calcium concentration is typically 1.2m M. Calculate the resting potential (at equilibrium) produced by the neuron as a result of the calcium ion concentration gradient. (Report your answer in mV ).
Arrange following the boxed information in sequence regarding the dissociation and reassociation of G proteins following the activation of a G protein coupled receptor. GTP-bound Ga, dissociates from B and y cuhunits Gas exchanges GTP for GDP Gas reassociates with By subunits and the rorentor reforms Binding of the ligand to a G-protein rounled recentor GTP-bound Gas binds and activates adenvlul rurlase GTP is hydrolyzed and GDP bound Gas suhunit dissoriates Conformational change Increased synthesis of CAMP from ATP

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Question: What is the stoichiometric ratio of epinephrine to the hybrid receptor (B-AR-EGFR)? O 1:1 O 1:4 O 1:2 O 2:1