The serotonin molecule has some remarkable properties. It is synthesized by two different two different sites, and, surprisingly, plays antagonistic functions on bone mass accrual at these two sites. When produced peripherally, serotonin acts as a hormone to inhibit bone formation. In contrast, when produced in the brain, serotonin acts as a neurotransmitter to exert a positive and dominant effect on bone mass accrual by enhancing bone formation and limiting bone resorption. The effect of genes at serotonin on bone biology could be harnessed pharmacologically to treat diseases such as osteoporosis.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Can you explain it in different words. Some easier words explanation. But please, do not copy it from the sites. Thanks

PMID: 20921133
PMCID: PMC2953449 DOI: 10.1083/jcb.201006123
Free PMC article
Abstract
The serotonin molecule has some remarkable properties. It is synthesized by two different genes at
two different sites, and, surprisingly, plays antagonistic functions on bone mass accrual at these two
sites. When produced peripherally, serotonin acts as a hormone to inhibit bone formation. In contrast,
when produced in the brain, serotonin acts as a neurotransmitter to exert a positive and dominant
effect on bone mass accrual by enhancing bone formation and limiting bone resorption. The effect of
serotonin on bone biology could be harnessed pharmacologically to treat diseases such as
osteoporosis.
Figures
Transcribed Image Text:PMID: 20921133 PMCID: PMC2953449 DOI: 10.1083/jcb.201006123 Free PMC article Abstract The serotonin molecule has some remarkable properties. It is synthesized by two different genes at two different sites, and, surprisingly, plays antagonistic functions on bone mass accrual at these two sites. When produced peripherally, serotonin acts as a hormone to inhibit bone formation. In contrast, when produced in the brain, serotonin acts as a neurotransmitter to exert a positive and dominant effect on bone mass accrual by enhancing bone formation and limiting bone resorption. The effect of serotonin on bone biology could be harnessed pharmacologically to treat diseases such as osteoporosis. Figures
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