Which of the following mechanisms of action could the drug from the above question potentially have to cause the described effects in male rats (so disruption of male sexual behavior when given prenatally but not when given in adulthood)? Group of answer choices Estrogen receptor antagonist or aromatase inhibitor Testosterone receptor antagonist Estrogen receptor antagonist Aromatase inhibitor

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Which of the following mechanisms of action could the drug from the above question potentially have to cause the described effects in male rats (so disruption of male sexual behavior when given prenatally but not when given in adulthood)?

Group of answer choices
Estrogen receptor antagonist or aromatase inhibitor
Testosterone receptor antagonist
Estrogen receptor antagonist
Aromatase inhibitor
Expert Solution
Step 1: Hormonal hypothesis of sexual differentiation

According to the hormonal hypothesis of sexuality and gender identity, just as exposure to specific hormones affects prenatal sex differentiation, it also affects an adult's later-emerging sexual orientation or gender identity. 
Sex variations in a wide range of behaviours, including sexual orientation, are thought to be caused by differences in brain structure that result from chemical messengers and genes interacting with developing brain cells. 
Later sex-typed behaviour may be influenced by prenatal variables that impact or interfere with how these hormones interact with the developing brain.

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