1a.Arrange these ligands in their order of potencies(high to low) 1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system. 1c. Which of the following has more affinity to bind to adrenergic receptors? And why? I. Epinephrine II. Isoproterenol III. Propranolol
1a.Arrange these ligands in their order of potencies(high to low) 1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system. 1c. Which of the following has more affinity to bind to adrenergic receptors? And why? I. Epinephrine II. Isoproterenol III. Propranolol
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
1a.Arrange these ligands in their order of potencies(high to low)
1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system.
1c. Which of the following has more affinity to bind to adrenergic receptors? And why?
I. Epinephrine
II. Isoproterenol
III. Propranolol

Transcribed Image Text:OH
Kа (им)
но
CH -CH2-NH-CH3
5
но
Epinephrine
OH
CH3
но
CH -CH2 -NH -CH
0.4
Isoproterenol
(agonist)
CH3
но
OH
CH3
о-CH2 — СH — CH2 —NH — СH
0.0046
CH3
Propranolol
(antagonist)
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