1a.Arrange these ligands in their order of potencies(high to low) 1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system. 1c. Which of the following has more affinity to bind to adrenergic receptors? And why? I. Epinephrine II. Isoproterenol III. Propranolol

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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1a.Arrange these ligands in their order of potencies(high to low)

1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system.

1c. Which of the following has more affinity to bind to adrenergic receptors? And why?
I. Epinephrine
II. Isoproterenol
III. Propranolol

 

 

OH
Kа (им)
но
CH -CH2-NH-CH3
5
но
Epinephrine
OH
CH3
но
CH -CH2 -NH -CH
0.4
Isoproterenol
(agonist)
CH3
но
OH
CH3
о-CH2 — СH — CH2 —NH — СH
0.0046
CH3
Propranolol
(antagonist)
Transcribed Image Text:OH Kа (им) но CH -CH2-NH-CH3 5 но Epinephrine OH CH3 но CH -CH2 -NH -CH 0.4 Isoproterenol (agonist) CH3 но OH CH3 о-CH2 — СH — CH2 —NH — СH 0.0046 CH3 Propranolol (antagonist)
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