G Proteins and Smooth Muscle Ca* L-type Ca** channel • The overall effect of Beta 2 agonism in the bronchioles is relaxation due to the Muscarinic 3 SR Ca** (Gq-R Beta 2 activation of cAMP and inhibition of MLCK IP3 Ca* (Gs-R) CM Са"-см CAMP Gi-R MLC ATP MLCK MLCP Relaxation Contraction Rho- kinase CGMP Gq-R NO

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