Recall that when we calculated the fraction of estrogen receptors occupied in the presence of 1 nM estradiol and 1 µM BPA, wefound that the fraction of receptors occupied with estradiol was 0.14 and the fraction of receptors occupied with BPA was 0.71.Calculate the concentration of free receptor in terms ofthe total concentration of receptor, Rtotal0.29R₁ total0.86Rtotal0.85R total0.15R totalConfirm the approximate value for the dissociationCalculate the concentration of free estradiol in terms ofthe total concentration of receptor, RtotalConfirm the approximate value for the dissociationconstant for the estrogen receptor-estradiol complex.

To calculate the concentration of free receptor (Rfree) in terms of the total concentration of…

Answered: Recall that when we calculated the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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From the Hill Plot below, the of the first binding event for the receptor-ligand system under study is: Q1 4nM Ο 10 μΜ -2 nM 2 nM Calculate the Hill Coefficient from the receptor-ligand binding data below: Q2 4 100 2 3 (0-1) 60 log 10 8 6 4 2 0 -2 -4 -6 -6 -4 -2 0 2 4 log [L] (nM) 6 8 10
1.Substituents exhibit strong steric repulsion at the GABAA receptor ？what does it means？？ 2. Substitutions at C-6, C-8, and C-9 lower the activity？where is C-6, C-8, and C-9 ？can anyone help to lable out？
2 of 16 Compound Binds to Elicits biological receptor response A Yes Yes B Yes No C No No Refer to the table above. Compound X is the natural ligand that binds to a receptor and stimulates a signal transduction pathway associated with the receptor. Based on the information given in the table, what are the roles of compounds A, B, and C? O A is an antagonist, B is an agonist, and C is a ligand. A is an agonist, B is an antagonist, and C has no role. A is a ligand, B has no role, and C is an antagonist. A is an agonist, B is an antagonist, and C is an agonist. A has no role, B is an agonist, and C is an antagonist.
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2+ Activation of 5-HT2A Increases cytosolic free Ca²+ Concentration ([Ca²+]) Via a Signaling cascade. At rest, neurons have a cytosolic Ca Concentration of 100nM. The ex- Tra cellular free calcium concentration is typically 1.2m M. Calculate the resting potential (at equilibrium) produced by the neuron as a result of the calcium ion concentration gradient. (Report your answer in mV ).
5.. A sample of cells has a total receptor concentration of 25 mM. Ninety percent of the receptors have bound ligand and the concentration of free ligand is 125 µM. Calculate the K for the receptor ligand interaction. (a) What is the AG° for binding for this interaction at 25°C?
What are the receptors involved in long term alcohol use binding and between GABBA agonist receptor and NDMA antagonist receptor, what will be the long term receptor changes?
Which of the following mechanisms of action could the drug from the above question potentially have to cause the described effects in male rats (so disruption of male sexual behavior when given prenatally but not when given in adulthood)? Group of answer choices Estrogen receptor antagonist or aromatase inhibitor Testosterone receptor antagonist Estrogen receptor antagonist Aromatase inhibitor
Using molecular cloning, a hybrid receptoer is produced that consists of the extracellular domain of the B-adrenergic receptor (B-AR) and the transmembrane and intracellular domains of the EGF receptor (EGFR). Question: What is the stoichiometric ratio of epinephrine to the hybrid receptor (B-AR-EGFR)? 1:1 O 1:4 O 1:2 2:1 O O O
why is there a difference between the stock solution concetration of chymotrypsin calculated from zero time y intercepts versus the stock solution label information?
fill in the blanks In signal transduction, termination of the active Gas is by ( ) and termination of the cAMP signal is by ( ).
Looking at Fig. 3a and 3b, how do you know that 3a has a significant difference and that Fig. 3b does not? In the euthyroid HT induces ultrastructure changes in frontal synapses section of the results section the authors wrote “Quantitatively, the ultrastructure of the frontal lobe neurons revealed lower synaptic density (Fig. 5c), fewer presynaptic vesicles (Fig. 5d), shorter active zone length (Fig. 5e), thinner postsynaptic densities (Fig. 5g), and decreased synaptic curvature (Fig. 5h) in the HT mice compared with those in the Con mice.” Based on this quote would you expect nerve transmission to be faster or slower in HT mice?

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