From the Hill Plot below, the of the first binding event for the receptor-ligand system under study is:Q14nMΟ 10 μΜ-2 nM2 nMCalculate the Hill Coefficient from the receptor-ligand binding data below:Q2410023(0-1) 60log1086420-2-4-6-6-4-202 4log [L] (nM)6810

The hill plot is a graph drawn based on the Hill equation given below.This identifies with the…

Answered: 8 From the Hill Plot below, the of the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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When the amount of ligand bound is in large excess compared to the protein, the fractional saturation is equal to: Group of answer choices 0, nothing is bound 0.5, this is the half-occupancy point which corresponds to K(D) 1, this is the full occupancy point Cannot be determined
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= 20 nM. The rate of receptor-ligand complex formation with an A receptor-ligand complex has a dissociation constant of Ka added ligand concentration of 10 µM is 5 × 10³ s¯¹. What is the value of the reverse rate constant, k_₁ ? k_₁ = 8-1
2 of 16 Compound Binds to Elicits biological receptor response A Yes Yes B Yes No C No No Refer to the table above. Compound X is the natural ligand that binds to a receptor and stimulates a signal transduction pathway associated with the receptor. Based on the information given in the table, what are the roles of compounds A, B, and C? O A is an antagonist, B is an agonist, and C is a ligand. A is an agonist, B is an antagonist, and C has no role. A is a ligand, B has no role, and C is an antagonist. A is an agonist, B is an antagonist, and C is an agonist. A has no role, B is an agonist, and C is an antagonist.
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Two proteins bind to the same ligand with the following Kd's. Protein 1: 10 μΜProtein 2: 100 nM Which protein would be bound to more ligand at a ligand concentration of 10 μM? (Assume a limiting concentration of each protein)

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8 From the Hill Plot below, the of the first binding event for the receptor-ligand system under study is: 10 Q1 4 nM Ο 10 μ. -2 nM 2 nM (0-1) 601 6 4 2 -2 Calculate the Hill Coefficient from the receptor-ligand binding data below: Q2 -4 4 100 2 3 -6 -6 -4 -2 0 2 4 6 8 10 log [L] (nM)