GPCR in the presence of one of these compounds. 0.5 0-0-0 0 A B ***** C 300-00 D 100 0.001 0.01 0.1 1 10 100 1000 A. Compounds A are full or almost full agonists. B. Compound B is a partial agonist. active receptor,
GPCR in the presence of one of these compounds. 0.5 0-0-0 0 A B ***** C 300-00 D 100 0.001 0.01 0.1 1 10 100 1000 A. Compounds A are full or almost full agonists. B. Compound B is a partial agonist. active receptor,
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Please explain this question and make me understand why D is the answer.
Transcribed Image Text:31. Investigation of a family of related compounds of a promising GPCR drug target showed a
range of activities that could be grouped into four categories (A-D) differing in their mode
of action. Select the FALSE statement based on the dose-ressponse curves obtained for
GPCR in the presence of one of these compounds.
0.5
0
A
B
C
0.001 0.01 0.1 1 10 100 1000
D
A.
Compounds A are full or almost full agonists.
Compound B is a partial agonist.
B.
C. The studied GPCR is a constitutively active receptor.
D. Compound C shows no effect, hence it is an antagonist.
E. Compounds D are inverse agonists with varying degree of efficacy.
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