Doxorubicin is a chemotherapeutic drug with an IC50 in MCF7 breast cancer cells of 0.01 microM. Assuming the cytotoxicity of doxorubicin follows 'classic' receptor theory what percentage of the cells will be viable following treatment of the cells with a concentration of doxorubicin of 0.01 microM? 10% O 0.01% O 90% O 50% 99.99%

Doxorubicin is a chemotherapeutic drug with an IC50 in MCF7 breast cancer cells of 0.01 microM. Assuming the cytotoxicity of doxorubicin follows 'classic' receptor theory what percentage of the cells will be viable following treatment of the cells with a concentration of doxorubicin of 0.01 microM? 10% O 0.01% O 90% O 50% 99.99%

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Similar questions

please help me with this problem
Researchers have suggested that sleep apnoea (the tendency to occasionally stop breathing when asleep) may worsen the effects of allergen-induced asthma. To investigate this possibility, Johnson and colleagues (2015), compared two groups of rats, a normal healthy non-allergic group, and a second group that were mildly allergic to ovalbumin. They subjected these rats to one of two treatments – 1) a 10-minute period of induced hypoxia (oxygen down to 10% of the air), representing the kind of temporary hypoxia that sufferers of sleep apnoea may be subjected to, and 2) a control (normal air) group. They then compared the respiratory function of both groups in these two treatments by using a two-factor ANOVA. (Questions are on the next page). Source df F P Rat type 1 21.88 <0.0001 Oxygen treatment 1 141.13 <0.0001 Rat type x oxygen treatment 1 15.68 <0.001 Residual 36 What is the result of the test of the…
The number of calories used during physical exercise is greater than the number of calories used for the movements themselves. This may be caused in part by exercise-induced expression of uncoupling protein 1 (UCP1) in subcutaneous fat. Subcutaneous fat is mostly white fat cells but can also contain brown fat cells in mice and humans. As part of a thermogenesis program, UCP1 directly reduces the proton gradient driving oxidative phosphorylation. UCP1 expression is a characteristic of brown fat cells only and is induced by the protein irisin. The data in Table 1 address the relationship between exercise and: • expression of UCP1 in subcutaneous fat cells, • expression of FNDC5 (a transmembrane protein in skeletal muscle plasma membranes), • blood levels of irisin (a soluble protein formed by cleaving the extracellular domain of FNDC5), and • expression of adiponectin (a hormone produced by white fat cells) in both wild-type mice and mice with overexpression skeletal muscle PGC-1a (a…
Metabolic syndrome is a clustering of various conditions including high blood pressure, high blood sugar, excess body fat, high serum triglycerides, and low high-density lipoproteins. Scientists studying metabolic syndrome cultured fibroblast cells from a metabolic syndrome patient and a healthy volunteer and challenged the cells to 100 nM insulin. Ten minutes after the stimulus was applied, they used a protein immunoblot to measure the amount of phosphorylated insulin receptor in the cultures. Use the passage to answer the question. Insulin, in addition to regulating blood glucose, also promotes satiety. Ghrelin, on the other hand, is a peptide hormone that promotes hunger. Which statement BEST predicts the effect of ghrelin release on the insulin receptor? A. It increases insulin receptor expression. B. It decreases insulin receptor expression. C. It increases insulin receptor phosphorylation. D. It decreases insulin receptor phosphorylation.
Nearly all immune deficiency diseases that result in impaired TH17 and ILC3 function lead to chronic mucocutaneous candidiasis (CMC), usually accompanied by increased susceptibility to pyogenic bacterial infections. However, a subset of these patients also show increased susceptibility to intracellular bacterial infections, such as those caused by Mycobacteria species. What is the explanation for why some, but not all, of these patients have increased susceptibility to intracellular bacteria and which patients fall into this category?
Viable Cell Concentration (cells ml¬1) Osmolarity = Time (h) 290 mOsm 1¯1 380 mOsm 1¬1 Osmolarity = Osmolarity = 435 mOsm 1¬1 4.2× 10ª 9.8 × 10ª 2.2 × 105 6.5× 105 1.1× 106 1.0× 106 9.7× 105 7.8× 105 7.0× 105 7.0× 105 6.5× 105 4.7× 105 4.2x 105 4.2 × 10ª 6.3 × 10* 1.2 x 105 2.2 × 105 4.1 × 105 5.1 × 105 7.9 × 105 7.7 × 105 6.0 × 105 5.5 x 105 3.5 × 105 1.7 × 105 1.3 × 105 < 10* 4.8 × 10ª 7.0 × 104 4.2 x 1 25 50 75 9.7 × 10* 1.6 x 105 2.5 x 105 100 125 150 4.1 × 105 5.9 × 105 5.4 × 105 4.4 × 105 2.6 × 105 1.2 × 105 8.8 × 10* 175 200 225 250 275 300 (a) Does medium osmolarity affect whether the hybridoma cells undergo a lag phase? (b) How does medium osmolarity affect the maximum specific growth rate of the cells? (c) How does medium osmolarity affect the maximum cell concentration achieved and the time taken to reach maximum cell density? (d) What effect does medium osmolarity have on the specific death rate of the cells during the culture death phase? Medium sterilization.
Based on data, which aptamer would consider to be the primary receptor for the FGF5 ligand? Explain your answer.
Describe one chemotherapeutic approach that can be used to treat prostate cancer? Your answer should include information about the molecular processes and interactions which are at the core of the treatment strategy
iii only
Biologic agents can block cell migration to sites of inflammation and reduce immune responses. Natalizumab is a humanized monoclonal antibody directed at the a4-integrin protein, a subunit of VLA-4, the binding partner of VCAM-1 expressed on endothelium in the central nervous system, and of a4b-integrin, the binding partner of MadCAM-1 expressed on endothelium in the gut. While natalizumab has had great success in alleviating the symptoms of autoimmune diseases such as multiple sclerosis and Crohn’s disease, a small number of patients have acquired life threatening infections of the neurotrophic virus, JC. Why are patients on natalizumab particularly susceptible to a virus infection of the central nervous system?
Induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Please provide information on induced pluripotent stem cells and their use as described above (model various diseases and screen drugs in these in vitro models). Please explain clearly and nicely. THANKS
which of hthe following would result in a persisting proliferation response to growth factor receptor activation after the ligand is no longer binding to its rceptor kinase? 1. Both a mutation that blocks the GTPas activity of Ras and a mutation that blocks the exchange of GDP with GTP would cause the response to persist. 2. a mutation that blocks the GTPas activity of Ras 3. neither a mutation that blocks the GTPas activity of Ras nor a mutation that blocks the exchange of GDP with GTP would cause the response to persist 4. a mutatiaon that blocks the exchange of GDP with GTP