All adrenoleukodystrophy patients carry the same mutation in the ABCD1 gene, however their clinical fates vary dramatically. Male patients, like Lorenzo from the film, have a 35-40% risk of developing the disease between 3 and 18 years of age whereas others develop it in adulthood. In adulthood, virtually all men and 80% of women with ALD develop a spinal cord disease. The disease caused by a mutation in ABCD1 leads to an increase in very long-chain fatty acids. These fatty acids cause stress to the endoplasmic reticulum of cells. This stress then leads to the destruction of myelin an important component in neural cells (we'll learn more about this later). Using a sheet of paper or electronically, draw a cell. (It doesn't have to be a specific type of cell any generic cell will do.) This cell is from a patient who suffers from adrenoleukodystrophy. Therefore, be sure to draw the following structures and make sure to label them: A. Plasma Membrane - doesn't need to be fancy B. Nucleus C. Nuclear Envelope D. Smooth and Rough Endoplasmic reticulum E. Peroxisome (looks just like a lysosome) F. Mitochondria G. Draw the accumulation of fatty acids near the endoplasmic reticulum.
All adrenoleukodystrophy patients carry the same mutation in the ABCD1 gene, however their clinical fates vary dramatically. Male patients, like Lorenzo from the film, have a 35-40% risk of developing the disease between 3 and 18 years of age whereas others develop it in adulthood. In adulthood, virtually all men and 80% of women with ALD develop a spinal cord disease. The disease caused by a mutation in ABCD1 leads to an increase in very long-chain fatty acids. These fatty acids cause stress to the endoplasmic reticulum of cells. This stress then leads to the destruction of myelin an important component in neural cells (we'll learn more about this later). Using a sheet of paper or electronically, draw a cell. (It doesn't have to be a specific type of cell any generic cell will do.) This cell is from a patient who suffers from adrenoleukodystrophy. Therefore, be sure to draw the following structures and make sure to label them: A. Plasma Membrane - doesn't need to be fancy B. Nucleus C. Nuclear Envelope D. Smooth and Rough Endoplasmic reticulum E. Peroxisome (looks just like a lysosome) F. Mitochondria G. Draw the accumulation of fatty acids near the endoplasmic reticulum.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
Related questions
Question
None
Transcribed Image Text:All adrenoleukodystrophy patients carry the same mutation in the ABCD1 gene, however their clinical fates vary
dramatically. Male patients, like Lorenzo from the film, have a 35-40% risk of developing the disease between 3 and 18
years of age whereas others develop it in adulthood. In adulthood, virtually all men and 80% of women with ALD
develop a spinal cord disease. The disease caused by a mutation in ABCD1 leads to an increase in very long-chain fatty
acids. These fatty acids cause stress to the endoplasmic reticulum of cells. This stress then leads to the destruction of
myelin an important component in neural cells (we'll learn more about this later).
Using a sheet of paper or electronically, draw a cell. (It doesn't have to be a specific type of cell any generic cell
will do.) This cell is from a patient who suffers from adrenoleukodystrophy. Therefore, be sure to draw the
following structures and make sure to label them:
A. Plasma Membrane - doesn't need to be fancy
B. Nucleus
C. Nuclear Envelope
D. Smooth and Rough Endoplasmic reticulum
E. Peroxisome (looks just like a lysosome)
F. Mitochondria
G. Draw the accumulation of fatty acids near the endoplasmic reticulum.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps with 1 images
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education