Since the query’s are matching does that mean the house mouse( mus musculus) is a good model to test in the human FGFR3 gene(achondroplasia). The NCBI blastp and reciprocal analysis are below
Since the query’s are matching does that mean the house mouse( mus musculus) is a good model to test in the human FGFR3 gene(achondroplasia). The NCBI blastp and reciprocal analysis are below
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Concept explainers
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
Question
Since the query’s are matching does that mean the house mouse( mus musculus) is a good model to test in the human FGFR3 gene(achondroplasia). The NCBI blastp and reciprocal analysis are below
![fibroblast growth factor receptor 3 isoform 3 precursor [Homo sapiens]
Sequence ID: NP_001156685.1 Length: 808 Number of Matches: 1
Range 1: 1 to 808
Score
Expect Method
Gaps
1478 bits(3827) 0.00) Compositional matrix adjust. 745/808(92%) 765/808(94%) 6/808 (0%)
VAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELS 58
G EQRVV RAAEVPGPEP QQEQ+ FGSGD VELS
Sbjct 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGOQEQLVFGSGDAVELS
60
Query 59
Sbjct 61
Query 119
CHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDAGVYSCQHRL TRRVLCH 118
C PPGG P GPTVW KDGTGLV S R+LVGPQRLQVLNASHED+G YSC+ RLT+RVLCH
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPORLOVLNASHEDSGAYSCRQRL TQRVLCH
120
Query 1 MVVPACVLVFCVAV--
M PAC L CVAV VAGA+SE
Identities
Positives
FSVRVTDAPSSGDDEDGEDVAE ----DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 174
FSVRVTDAPSSGDDEDGED AE DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
180
Sbjct 121
Query 175
Sbjct 181
234
240
Query
294
235 YTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
YTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Query 295
300
DGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQA
354
Sbjct 301
DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA
360
Query 355 AEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFP 414
AEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRLRSPPKKGLGSPTVHK+SRFP
Sbjct 361 AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420
474
LKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPL
Query 415
Sbjct 421
480
Query 475 GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 534
GEGCFGQVVMAEAIGIDKDR AKPVTVAVKMLKDDATDKDLSDLVS EMEMMKMIGKHKNI
GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 540
Sbjct 481
Query 535
Sbjct 541
Query 595
INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRL PEEQLTCKDLVSCA 594
INLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCA
INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600
YQVARGMEYLASQKCIHRDLAARNVLV ONVMKIADFGLARDVHNLDYYKKT TNGRLPV 654
Sbjct 601
YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV
YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKL LKEGHRMDKPAS 714
720
Query 655
Sbjct 661
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
NPTPSISWLKNG+EFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
DGTPYVTVLKSWISE+VEAD RLRLANVSERDGGEYLCRATNFIGVAEKAFWL VHGP+A
LKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELELPADPKWELSR RLTLGKPL
LKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSE LELPADPKWELSRARLTLGKPL
Frame
SSSSSGDDSVF THDL LPPGPPSNGGPRT 802
SSSSSGDDSVF HDLLPP PPS+GG RT
SSSSSGDDSVFAHDL LPPAPPSSGGSRT
808
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA+
KWMAPEALFDRVYTHOSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN
Query 715 CTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTP 774
CTHDLYMIMRECWHA PSQRPTFKQLVEDLDR+LTVTSTDEYLDLS PFEQYSPGGQDTP
CTHDLYMIMRECWHAAPSORPTFKOLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780
Sbjct 721
Query 775
Sbjct 781](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4c5addd0-3107-4aed-8c6b-6b5b2f9fadb0%2F857e2098-9dc7-4816-b277-96f89d39a63d%2Fbxyulrc_processed.jpeg&w=3840&q=75)
Transcribed Image Text:fibroblast growth factor receptor 3 isoform 3 precursor [Homo sapiens]
Sequence ID: NP_001156685.1 Length: 808 Number of Matches: 1
Range 1: 1 to 808
Score
Expect Method
Gaps
1478 bits(3827) 0.00) Compositional matrix adjust. 745/808(92%) 765/808(94%) 6/808 (0%)
VAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELS 58
G EQRVV RAAEVPGPEP QQEQ+ FGSGD VELS
Sbjct 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGOQEQLVFGSGDAVELS
60
Query 59
Sbjct 61
Query 119
CHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDAGVYSCQHRL TRRVLCH 118
C PPGG P GPTVW KDGTGLV S R+LVGPQRLQVLNASHED+G YSC+ RLT+RVLCH
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPORLOVLNASHEDSGAYSCRQRL TQRVLCH
120
Query 1 MVVPACVLVFCVAV--
M PAC L CVAV VAGA+SE
Identities
Positives
FSVRVTDAPSSGDDEDGEDVAE ----DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 174
FSVRVTDAPSSGDDEDGED AE DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
180
Sbjct 121
Query 175
Sbjct 181
234
240
Query
294
235 YTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
YTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Query 295
300
DGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQA
354
Sbjct 301
DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA
360
Query 355 AEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFP 414
AEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRLRSPPKKGLGSPTVHK+SRFP
Sbjct 361 AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420
474
LKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPL
Query 415
Sbjct 421
480
Query 475 GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 534
GEGCFGQVVMAEAIGIDKDR AKPVTVAVKMLKDDATDKDLSDLVS EMEMMKMIGKHKNI
GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 540
Sbjct 481
Query 535
Sbjct 541
Query 595
INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRL PEEQLTCKDLVSCA 594
INLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCA
INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600
YQVARGMEYLASQKCIHRDLAARNVLV ONVMKIADFGLARDVHNLDYYKKT TNGRLPV 654
Sbjct 601
YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV
YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKL LKEGHRMDKPAS 714
720
Query 655
Sbjct 661
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
NPTPSISWLKNG+EFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
DGTPYVTVLKSWISE+VEAD RLRLANVSERDGGEYLCRATNFIGVAEKAFWL VHGP+A
LKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELELPADPKWELSR RLTLGKPL
LKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSE LELPADPKWELSRARLTLGKPL
Frame
SSSSSGDDSVF THDL LPPGPPSNGGPRT 802
SSSSSGDDSVF HDLLPP PPS+GG RT
SSSSSGDDSVFAHDL LPPAPPSSGGSRT
808
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA+
KWMAPEALFDRVYTHOSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN
Query 715 CTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTP 774
CTHDLYMIMRECWHA PSQRPTFKQLVEDLDR+LTVTSTDEYLDLS PFEQYSPGGQDTP
CTHDLYMIMRECWHAAPSORPTFKOLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780
Sbjct 721
Query 775
Sbjct 781
Transcribed Image Text:Score
Expect Method
Positives
Gaps Frame
1506 bits(3898) 0.0() Compositional matrix adjust. 736/796(92%) 755/796(94%) 6/796(0%)
Query 1
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
PAC L CVAV VAGA+SE G EQRVV RAAEVPGPEP QQEQ+ FGSGD VELS
MVVPACVLVFCVAV--VAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELS 58
Sbjct 1
Query 61
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTORVLCH 120
Sbjct 59 CHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLOVLNASHEDAGVYSCQHRLTRRVLCH 118
Query 121
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
174
Sbjct 119
FSVRVTDAPSSGDDEDGEDVAEDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAG
Query 181
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWS LVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNG+EFRGEHRIGGIKLRHOQWS LVMESVVPSDRGNYTCVVENKFGSIROT
Sbjct 175 NPTPSISWLKNGKEFRGEHRIGGIKLRHOOWS LVMESVVPSDRGNYTCVVENKFGSIROT 234
M
C PPGG P GPTVW KDGTGLV S R+LVGPQRLQVLNASHED+G YSC+ RLT+RVLCH
FSVRVTDAPSS GDDEDGED AEDTG
Identities
APYWTRPERMDKKLLAVPAANTVRFRCPAAG
Query 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct 235 YTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 294
Query 301 DGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRA
360
354
Sbjct 295
Query 361
AEEELVEADEAGSVYAGI LSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFP 420
AEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRLRSPPKKGLGSPTVHK+SRFP
Sbjct 355 AEEELMETDEAGSVYAGVLSYGVVFFLFILWVAAVILCRLRSPPKKGLGSPTVHKVSRFP 414
Query 421 LKROVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPL
480
474
Sbjct 415
Query 481 GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML KDDATDKDLSDLVSEMEMMKMIGKHKNI 540
Sbjct 475 GEGCFGQVVMAEAIGIDKDRTAKPVTVAVKML KDDATDKDLSDLVSEMEMMKMIGKHKNI 534
Query 541 INLLGACTQGGPLYVLVEYAAKGNL REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600
INLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCA
INLLGACTOGGPLYVLVEYAAKGNL REFLRARRPPGMDYSFDACRL PEEQLTCKDLVSCA 594
Sbjct 535
Query 601 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660
YOVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV
Sbjct 595 YOVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV
654
Query 661
KWMAPEAL FDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN 720
Sbjct 655
714
Query 721
CTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTP 780
CTHDLYMIMRECWHA PSQRPTFKQLVEDLDR+LTVTSTDEYLDLS PFEQYSPGGQDTP
CTHDLYMIMRECWHAVPSORPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTP 774
Sbjct 715
Query 781
Sbjct 775
DGTPYVTVLKSWISE+VEAD RLRLANVSERDGGEYLCRATNFIGVAEKAFWL VHGP+A
DGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQA
LKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELELPADPKWELSR RLTLGKPL
LKROVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPL
GEGCFGQVVMAEAIGIDKDR AKPVTVAVKML KDDATDKDLSDLVS EMEMMKMIGKHKNI
SSSSSGDDSVFAHDLL 796
SSSSSGDDSVF HDLL
SSSSSGDDSVF THDLL 790
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA+
KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAS
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