6 7 8 Chromosome 9 10 11 12 13 14 15 16 17 18 19202122 a) From the plot above. Which chromosome/s would be the focus of your future studies in search of the genes that might be responsible fo gout? Chromosome/s b) Briefly justify your choice/s for item a: I choose those chromosomes because
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
please answer the blanks for part a and b
![**THEME 2: About association mapping:**
Imagine you are studying the genetic basis of gout using GWAS and have available molecular markers (single nucleotide polymorphism tags or SNP tags) located all over the genome. Your results are displayed below.
*[Image displays a Manhattan plot illustrating the p-values of genetic variants across chromosomes. Each dot represents a SNP, and the y-axis shows the negative logarithm of the p-values (-log10 P-value). Chromosomes are represented on the x-axis, with chromosome 4 having the most significant peaks labeled ABCG2 and SLC2A9, and chromosome 11 having a peak labeled MYL2-CUX2.]*
a) From the plot above, which chromosome/s would be the focus of your future studies in search of the genes that might be responsible for gout? Chromosome/s ______ .
b) Briefly justify your choice/s for item a: I choose those chromosomes because ____________ .](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4143f45a-5c96-4449-af2f-abda697f3e91%2F1fe40fcb-75bc-4fe6-aeb8-b48fbdaabc36%2Fz4184sd_processed.png&w=3840&q=75)
Genome refers to the complete set of genes or the complete genetic makeup of an individual organism. Genes are responsible for controlling social characteristics (traits) in an organism.
Genome-wide association studies are research studies that involve the study of the effects of genes and how these genes are linked to their specific traits.
In the GWAS, the small genomic variants called the SNPs (Small Nucleotide Polymorphisms) are studied which are statistically correlated to their traits/ disease.
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