Wild type 0.09 E104K G238S --+-- 0.13 1.41 A42G G238S ‒‒‒ E104K A42G -++-- 1.41 --+-+ 362 G238S A42G 32.0 A42G g4205a A42G --++ E104T -++-+ -+--+ M182T -+-++ 22.6 g4205a 2050 ++--+ 362 362 --+++ 362 +++ 362 M182T E104K A42G E104K g4205a E104K -++++ 94205a 2900 +++-+ 1650 ++++ 2050 M182T A42G +++++ Max. resistance allele 4100 First mutation Second mutation Third mutation Fourth mutation Fifth mutation
Wild type 0.09 E104K G238S --+-- 0.13 1.41 A42G G238S ‒‒‒ E104K A42G -++-- 1.41 --+-+ 362 G238S A42G 32.0 A42G g4205a A42G --++ E104T -++-+ -+--+ M182T -+-++ 22.6 g4205a 2050 ++--+ 362 362 --+++ 362 +++ 362 M182T E104K A42G E104K g4205a E104K -++++ 94205a 2900 +++-+ 1650 ++++ 2050 M182T A42G +++++ Max. resistance allele 4100 First mutation Second mutation Third mutation Fourth mutation Fifth mutation
Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter2: Basic Hematology
Section2.3: Microhematocrit
Problem 4RQ
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Question
Below is a figure showing possible trajectories to maximum resistance to cefotaxime. Numbers indicate cefotaxime resistance in micrograms per ml. What is the most likely pathway to max resistance?
a. G238S→ g4205a →A42G→M182T→E104K
b. G238S→ A42G →E406F→M182T→g4205a
c. E104K→A42G→G238S→M182T→g4205a
d. G238S→E104K→A42G→M182T→g4205a
Transcribed Image Text:Wild type
0.09
E104K
G238S
--+--
0.13
----+
1.41
A42G
G238S
----
E104K
A42G
-++--
1.41
--+-+
362
22.6
G238S
A42G
32.0
A42G
g4205a
A42G
-++-+
-+--+ M182T -+-++
2050
g4205a
++--+
362
---++ E104T --+++
362
362
+--++
362
M182T
E104K
A42G
E104K
g4205a
E104K
-++++ 94205a
2900
+++-+
1650
- ++++
2050
M182T
A42G
+++++
Max. resistance
allele
4100
First mutation Second mutation Third mutation Fourth mutation Fifth mutation
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