A series of novel phenadoxone derivatives without mu2 receptor activity (mu2 activity is responsible for physical dependence) proposed to be developed as analgesics is shown below. Addition of which heterocyclic substituent R to phenadoxone is likely to cause the most binding of the corresponding derivative to plasma proteins? Use the additivity of approximate estimates of logP to answer this question.[Image of chemical structure with description: Phenadoxone derivatives, followed by various heterocyclic substituents]- **A. Azetidine**- **B. Thiophene** (selected)- **C. Oxetane**- **D. Furan**- **E. Pyrrole**The correct answer is indicated by highlighting "B. Thiophene."### Explanation:The image includes a chemical structure labeled as *phenadoxone derivatives* with a placeholder for various substituents denoted by "R." The substituents include azetidine, thiophene, oxetane, furan, and pyrrole. The task is to determine which substituent is likely to cause the most binding to plasma proteins based on logP values.Thiophene is highlighted, indicating it is the most probable substituent to increase binding to plasma proteins when attached to phenadoxone, considering the logP values.

A series of novel phenadoxone derivatives without mu2 receptor activity (mu2 activity is responsible for physical dependence) proposed to be developed as analgesics is shown below. Addition of which heterocyclic substituent R to phenadoxone is LIKELY to cause the MOST binding of the corresponding derivative to plasma proteins? Use the additivity of approximate estimates of logP to answer this question. phenadoxone derivatives R= A. Azetidine B. Thiophene C. Oxetane D. Furan E. Pyrrole -NH

A series of novel phenadoxone derivatives without mu2 receptor activity (mu2 activity is responsible for physical dependence) proposed to be developed as analgesics is shown below. Addition of which heterocyclic substituent R to phenadoxone is LIKELY to cause the MOST binding of the corresponding derivative to plasma proteins? Use the additivity of approximate estimates of logP to answer this question. phenadoxone derivatives R= A. Azetidine B. Thiophene C. Oxetane D. Furan E. Pyrrole -NH

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