In one type of hemoglobin mutant the amino acid change generates a strong ionic interaction stabilizing the T state conformation, but only under conditions of lower pH, e.g., at pH 7.2 compared to pH 7.6. Explain what effect this mutation would have on the amount of O2 delivered to the tissue O More O2 delivered to the tissue because the R-T equilibrium would be shifted to the T state in tissues. More O2 delivered to the tissue because the R-T equilibrium would be shifted to the T state in lungs. Less O₂ delivered to the tissue because the R-T equilibrium would be shifted to the T state in lungs. Less O2 delivered to the tissue because the R-T equilibrium would be shifted to the T state in tissues. More O2 delivered to the tissue because the R-T equilibrium would be shifted to the R state in tissues.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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In one type of hemoglobin mutant the amino acid change generates a strong
ionic interaction stabilizing the T state conformation, but only under
conditions of lower pH, e.g., at pH 7.2 compared to pH 7.6. Explain what
effect this mutation would have on the amount of O2 delivered to the tissue.
More O2 delivered to the tissue because the R-T equilibrium would be
shifted to the T state in tissues.
More O₂ delivered to the tissue because the R-T equilibrium would be
shifted to the T state in lungs.
Less O2 delivered to the tissue because the R-T equilibrium would be
shifted to the T state in lungs.
Less O₂ delivered to the tissue because the R-T equilibrium would be
shifted to the T state in tissues.
More O2 delivered to the tissue because the R-T equilibrium would be
shifted to the R state in tissues.
Transcribed Image Text:In one type of hemoglobin mutant the amino acid change generates a strong ionic interaction stabilizing the T state conformation, but only under conditions of lower pH, e.g., at pH 7.2 compared to pH 7.6. Explain what effect this mutation would have on the amount of O2 delivered to the tissue. More O2 delivered to the tissue because the R-T equilibrium would be shifted to the T state in tissues. More O₂ delivered to the tissue because the R-T equilibrium would be shifted to the T state in lungs. Less O2 delivered to the tissue because the R-T equilibrium would be shifted to the T state in lungs. Less O₂ delivered to the tissue because the R-T equilibrium would be shifted to the T state in tissues. More O2 delivered to the tissue because the R-T equilibrium would be shifted to the R state in tissues.
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