A point mutation in Hb diminishes hydrophobicity at the heme. Which of the following impacts would you predict?.Increased oxidation of Fe2+ and loss of O2 binding b.Decreased negative charges needed at the dimer/dimer interface to stabilize the T-state c.Decreased positive charges needed at the dimer/dimer interface to stabilize the T-state d.Shift the O2 binding curve of Hb to the left e.Decreased affinity for BPG in the T-state

Hb hemoglobin carries O2 in the blood during the gaseous exchange.

Answered: A point mutation in Hb diminishes…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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A point mutation in Hb diminishes hydrophobicity at the heme. Which of the following impacts would you predict?

.	Increased oxidation of Fe²⁺ and loss of O₂ binding
	b.	Decreased negative charges needed at the dimer/dimer interface to stabilize the T-state
	c.	Decreased positive charges needed at the dimer/dimer interface to stabilize the T-state
	d.	Shift the O₂ binding curve of Hb to the left
	e.	Decreased affinity for BPG in the T-state

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