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Explain the logic behind having [ADP] regulate the conversion of ribose-5-phosphate to PRPP. Does ADP inhibit or activate this reaction?

Explain the logic behind having [ADP] regulate the conversion of ribose-5-phosphate to PRPP. Does ADP inhibit or activate this reaction?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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**Question:** Explain the logic behind having [ADP] regulate the conversion of ribose-5-phosphate to PRPP. Does ADP inhibit or activate this reaction? **Answer on Educational Website:** ADP serves as a regulatory molecule in metabolism, influencing the synthesis of essential precursor molecules. In the conversion of ribose-5-phosphate to PRPP (5-phosphoribosyl-1-pyrophosphate), ADP typically acts as an inhibitor rather than an activator. The logic behind this regulation is based on cellular energy needs and nucleotide balance. High levels of ADP usually indicate low energy availability within the cell. During such conditions, it is beneficial for the cell to conserve its resources and inhibit pathways that lead to further nucleotide synthesis, thus preventing unnecessary ATP expenditure. Conversely, when energy levels are sufficient, and ADP levels are low, the pathway can proceed, ensuring the availability of PRPP for nucleotide synthesis when required for DNA and RNA production. Therefore, ADP's role as an inhibitor in this reaction helps maintain cellular energy efficiency and balance in nucleotide levels.
Transcribed Image Text:**Question:** Explain the logic behind having [ADP] regulate the conversion of ribose-5-phosphate to PRPP. Does ADP inhibit or activate this reaction? **Answer on Educational Website:** ADP serves as a regulatory molecule in metabolism, influencing the synthesis of essential precursor molecules. In the conversion of ribose-5-phosphate to PRPP (5-phosphoribosyl-1-pyrophosphate), ADP typically acts as an inhibitor rather than an activator. The logic behind this regulation is based on cellular energy needs and nucleotide balance. High levels of ADP usually indicate low energy availability within the cell. During such conditions, it is beneficial for the cell to conserve its resources and inhibit pathways that lead to further nucleotide synthesis, thus preventing unnecessary ATP expenditure. Conversely, when energy levels are sufficient, and ADP levels are low, the pathway can proceed, ensuring the availability of PRPP for nucleotide synthesis when required for DNA and RNA production. Therefore, ADP's role as an inhibitor in this reaction helps maintain cellular energy efficiency and balance in nucleotide levels.
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