-Inhibitor +Inhibitor [S] (mM) V&ν βσπ:(μmol/sec) ν0&νβσπ: &νβσπ: (μmol/sec) 0.0001 33 17 0.0005 71 50 0.001 83 67 0.005 96 91 0.01 98 95 What is the TYPE of iinhibitor?
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![-Inhibitor
+Inhibitor
[S] (mM)
Vη&νβσπ: (μmol/sec).
ν0&νβσπ;&νβσπ:(μmol/sec)
0.0001
33
17
0.0005
71
50
0.001
83
67
0.005
96
91
0.01
98
95
What is the TYPE of iinhibitor?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F776b81b2-5984-443d-93b2-d351507602c0%2F17659a97-21df-4f54-b51c-3e21f8c8ed2a%2F2zfbltb_processed.png&w=3840&q=75)
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- Why valinomycin is highly selective for K+ relative to Na+? (Subject: Biomembrane)An experiment was carried out to measure the reaction rate of hydrolysis of acetylcholme (substrate) with serum enzymes (Eadie, 1949). In the experiment, two experiments were conducted, namely experiment 1 without using a prostigmine inhibitor and experiment 2 using a prostigmine inhibitor at 1.5 x 10^-7 mol/l. the data obtained are: a. Is prostigmine competitive or noncompetitive inhibitor? b. determine the value of km and rmax for the two experiments, compareThe plasma profiles of codeine (COD) and metabolites for 2 individuals (labeled A and B) are shown below. The X-axis is time in hours after an oral dose of codeine. [M=morphine; C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM (ignore)]. Note the data is shown on a log scale on the Y-axis. (A) Which individual is the poor metabolizer? Explain how you know this from the profiles? (B) Is this a problem for cough suppression? Explain. -CH HO Codeine COD 10 000 1000 C6G COD 100 M3G M6G NM 10 M 10 20 30 0 10 20 30 Plasma concentration (nmol I-)
- How was thermal stability measured in this paper and describe how GRL-1720 and 5h affect the thermal stability of Mpro and which drug has the larger effect? https://www.nature.com/articles/s41467-021-20900-6MAP= CO x TPR / 80 I don't understand the value of TPR how do I get this number?Which patch clamp technique should be used if you want to investigate the effect a compound has presynaptically with varying concentration?
- What is the weight of epinephrine (in grams) required to make the prescription? What is the volume of water (in milliliters) needed to make the preparation isotonic?Which of the following protein domains would you expect to find in an "easily druggable" target but NOT in an "undruggable" target. An easily druggable target is defined as a target with an easily accessible active site than can be activated or inhibited. Please Explain. Answer Choices: A) Extracellular domain B) Intracellular domain C) Membrane Spanning domain D) ATP-binding domain E) Protein Binding domainDifferentiate HbA1c from Fructosamine. Give 3 comparisons
- A. Which one of the following is an example of affinity chromatography? Select all that apply. a) Hormone – receptor interaction b) Enzyme – substrate interaction c) Antigen-antibody interaction d) All of the above e) Cytochrome C – DEAE matrix B. If your sepharose beads are covalently attached to adrenaline hormone, which of the following protein is most likely purified by affinity chromatography? a) Receptor tyrosine kinase (RTK) b) Calmodulin c) GPCR d) Protein kinase A C. Which of the following malate dehydrogenase (MDH) has a 'peptide epitope tag'? a) MDH-HA b) MDH-GST c) MDH-GFP e) All of them D. To elute target proteins from an affinity chromatography matrix, which of the following conditions would be the most appropriate? a) Low salt concentrations b) High salt concentrations c) Adding a soluble ligand that competes with the affinity tagged protein for binding to the column d) Just keep washing buffer through the column, isocratic elutionThe Graph below shows the binding curves of two proteins (A and B) for the same ligand (L). Use this Graph and determine the dissociation constant, K, for both proteins. Which protein (A or B) has a greater affinity for ligand L? Which of the two proteins would be more easily inhibited by an antagonist? 1.0 Y 0.5 2 A 4 6 B 8 [L] (μM) 10 12 14 16What is neomycin phosphotransferase (designated neor)?
