One of the pathways required for neural tube closure is the WNT signaling pathway. The WNT receptor WLS and WNT co-receptor TMEM132a are needed for WNT secretion and signaling. Spina bifida (caudal NTD) is seen in WLS homozygous mutant mice (wwTT) as well as in TMEM132a homozygous mutant mice (WWtt). When a male mouse heterozygous for the Wls mutation (WwTT) is mated with a female mouse heterozygous for the Tmem132a mutation (WWTt), you observe ~25% of the offspring have spina bifida. A) Of the mice pups from the above cross, what genotype do you predict corresponds to the spina bifida phenotype? B) Based on your predicted genotype, what is one possible reason that these mice have spina bifida?
One of the pathways required for neural tube closure is the WNT signaling pathway. The WNT receptor WLS and WNT co-receptor TMEM132a are needed for WNT secretion and signaling. Spina bifida (caudal NTD) is seen in WLS homozygous mutant mice (wwTT) as well as in TMEM132a homozygous mutant mice (WWtt). When a male mouse heterozygous for the Wls mutation (WwTT) is mated with a female mouse heterozygous for the Tmem132a mutation (WWTt), you observe ~25% of the offspring have spina bifida. A) Of the mice pups from the above cross, what genotype do you predict corresponds to the spina bifida phenotype? B) Based on your predicted genotype, what is one possible reason that these mice have spina bifida?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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One of the pathways required for neural tube closure is the WNT signaling pathway. The WNT receptor WLS and WNT co-receptor TMEM132a are needed for WNT secretion and signaling. Spina bifida (caudal NTD) is seen in WLS homozygous mutant mice (wwTT) as well as in TMEM132a homozygous mutant mice (WWtt).
When a male mouse heterozygous for the Wls mutation (WwTT) is mated with a female mouse heterozygous for the Tmem132a mutation (WWTt), you observe ~25% of the offspring have spina bifida.
- A) Of the mice pups from the above cross, what genotype do you predict corresponds to the spina bifida
phenotype ?
- B) Based on your predicted genotype, what is one possible reason that these mice have spina bifida?
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