Homework Help is Here – Start Your Trial Now!
Science
Biology
You are studying a cell line that expresses both GPCR-A and GPCR-B, each receptor binds the same ligand but activates different heterotrimeric G proteins that act on adenylyl cyclase. GPCR-A causes an increase in adenylyl cyclase activity, while GPCR-B causes an decrease in adenylyl cyclase activity. There is a basal level of adenylyl cyclase activity that produces a baseline CAMP concentration. Which of the following mutations would decrease the intracellular levels of CAMP upon ligand addition? Select all that apply. A mutation in Gi that prevents release of bound GDP A mutation in GPCR-B that prevents G protein activation A mutation in GPCR-A that prevents G protein activation A mutation in Gs that prevents release of bound GDP

You are studying a cell line that expresses both GPCR-A and GPCR-B, each receptor binds the same ligand but activates different heterotrimeric G proteins that act on adenylyl cyclase. GPCR-A causes an increase in adenylyl cyclase activity, while GPCR-B causes an decrease in adenylyl cyclase activity. There is a basal level of adenylyl cyclase activity that produces a baseline CAMP concentration. Which of the following mutations would decrease the intracellular levels of CAMP upon ligand addition? Select all that apply. A mutation in Gi that prevents release of bound GDP A mutation in GPCR-B that prevents G protein activation A mutation in GPCR-A that prevents G protein activation A mutation in Gs that prevents release of bound GDP

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question
You are studying a cell line that expresses both GPCR-A and GPCR-B, each receptor binds the same ligand but activates different heterotrimeric G proteins that act on adenylyl cyclase. GPCR-A causes an increase in adenylyl cyclase activity, while GPCR-B causes an decrease in adenylyl cyclase activity. There is a basal level of adenylyl cyclase activity that produces a baseline CAMP concentration. Which of the following mutations would decrease the intracellular levels of cAMP upon ligand addition? Select all that apply. A mutation in Gi that prevents release of bound GDP A mutation in GPCR-B that prevents G protein activation A mutation in GPCR-A that prevents G protein activation A mutation in Gs that prevents release of bound GDP
Transcribed Image Text:You are studying a cell line that expresses both GPCR-A and GPCR-B, each receptor binds the same ligand but activates different heterotrimeric G proteins that act on adenylyl cyclase. GPCR-A causes an increase in adenylyl cyclase activity, while GPCR-B causes an decrease in adenylyl cyclase activity. There is a basal level of adenylyl cyclase activity that produces a baseline CAMP concentration. Which of the following mutations would decrease the intracellular levels of cAMP upon ligand addition? Select all that apply. A mutation in Gi that prevents release of bound GDP A mutation in GPCR-B that prevents G protein activation A mutation in GPCR-A that prevents G protein activation A mutation in Gs that prevents release of bound GDP
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Cell signaling
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS