Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter32: The Reception And Transmission Of Extracellular Information
Section: Chapter Questions
Problem 3P
Related questions
Question
If neither Viagra or ginseng works to fix the cat's problem, PKG would be considered “broken” in this signalling pathway, Why?
![LOCALLY PRODUCED
NITRIC OXIDE
Ca2*
EXPORT
PDE5
INHIBITORS
Ca2+
SEQUESTRATION,
Ca2+
RELEASE
5'-GMP
GC
P'Lamban
GTP
IP3
Receptor
Ca2+
PDE5
KCGMP
PKG
MLC P'tase
MLC
MLC-P
MLCK
RELAXATION
CONTRACTION
BK K* CHANNEL](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F5a067f74-d5d5-4ecf-b796-f27fcc462fe5%2F4e90d473-afd1-4693-815b-c4bb787ba879%2F21xygr_processed.png&w=3840&q=75)
Transcribed Image Text:LOCALLY PRODUCED
NITRIC OXIDE
Ca2*
EXPORT
PDE5
INHIBITORS
Ca2+
SEQUESTRATION,
Ca2+
RELEASE
5'-GMP
GC
P'Lamban
GTP
IP3
Receptor
Ca2+
PDE5
KCGMP
PKG
MLC P'tase
MLC
MLC-P
MLCK
RELAXATION
CONTRACTION
BK K* CHANNEL
![Smooth Muscle
Cell
Nitroglycerin
Guanylyl Cyclase
(inactive)
Nitric Oxide .
GTP
N:O-Guanylyl Cyclase
(active)
Nitric Oxide
CGMP
Inactive PKG
(N:O)
fCitrulline
Activated PKG
ATP
Nitric
Oxide
Synthase
Proteins
Phospho-Proteins
Ca2
Сам
Lowering of Ca²*
Desensitization to Ca2+
L-Arginine
Endothelial
Or Neuronal
Cell
Relaxation](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F5a067f74-d5d5-4ecf-b796-f27fcc462fe5%2F4e90d473-afd1-4693-815b-c4bb787ba879%2Fbzha6gw_processed.png&w=3840&q=75)
Transcribed Image Text:Smooth Muscle
Cell
Nitroglycerin
Guanylyl Cyclase
(inactive)
Nitric Oxide .
GTP
N:O-Guanylyl Cyclase
(active)
Nitric Oxide
CGMP
Inactive PKG
(N:O)
fCitrulline
Activated PKG
ATP
Nitric
Oxide
Synthase
Proteins
Phospho-Proteins
Ca2
Сам
Lowering of Ca²*
Desensitization to Ca2+
L-Arginine
Endothelial
Or Neuronal
Cell
Relaxation
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