This is a tyrosine kinase receptor. a. Briefly describe the action of the receptor upon binding to the logand. b. There are several intracellular pathway possibilities for downstream responses. How might this receptor be able to selectively activate one particular pathway over another?
This is a tyrosine kinase receptor.
a. Briefly describe the action of the receptor upon binding to the logand.
b. There are several intracellular pathway possibilities for downstream responses. How might this receptor be able to selectively activate one particular pathway over another?
RTKs (Receptor Tyrosine Kinase) are single-pass, type I receptors mostly resident in the plasma membrane. Generally, RTKs are activated through ligand-induced oligomerization, typically dimerization, which induce change in confirmation of the cytoplasmic tyrosine kinase domains. For most RTKs, this confirmation change facilitates autophosphorylation in trans of tyrosine residues in the kinase activation loop thus inducing to stabilize the active state of the kinase.
These and other phosphotyrosine residues serve as recruitment sites for a host of down-stream signaling proteins — enzymes and adapter/scaffolding proteins etc
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