Binding EGF to the EGF receptor causes phosphorylation of tyrosines on the cytoplasmic tail of the receptor. Which of the following best describes the mechanism by which this phosphorylation activates downstream signaling complexes? Select one A. Causes degradation of receptor by proteasome pathway B. Causes EGF receptor to be internalized so it can interact directly with downstream signaling molecules C. Tyrosine phosphorylation alters 3D structure of downstream signaling proteins causing them to change from an inactive to active conformation D. Causes release of EGF from receptor E. Alters the localization of downstream signaling partners in the cytoplasm
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Binding EGF to the EGF receptor causes phosphorylation of tyrosines on the cytoplasmic tail of the receptor. Which of the following best describes the mechanism by which this phosphorylation activates downstream signaling complexes? Select one
A. Causes degradation of receptor by proteasome pathway
B. Causes EGF receptor to be internalized so it can interact directly with downstream signaling molecules
C. Tyrosine phosphorylation alters 3D structure of downstream signaling proteins causing them to change from an inactive to active conformation
D. Causes release of EGF from receptor
E. Alters the localization of downstream signaling partners in the cytoplasm
Tyrosine kinases are essential mediators of this sign transduction process, main to mobileular/cellular proliferation, differentiation, migration, metabolism and programmed mobileular death. Tyrosine kinases are a own circle of relatives of enzymes, which catalyzes phosphorylation of pick out tyrosine residues in goal proteins, the use of ATP.
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