In this mechanim of receptor regulation, there is uncoupling of the signaling pathway. Even though the ligand is bound to the receptor located in the plasma membrane, downstream signaling is not occuring. This is best described as: Answers A-D A receptor internalization B receptor desensitization C receptor sensitization 5 D receptor downregulation
Introduction
Receptor regulation is the homeostatic increase or decrease in receptor activity/ number in response to activation or blockage.
1.Homologous receptor regulation
Activation of one receptor could trigger procecesses that regulate same receptor
2 heterologous receptor regulation
Activation of one receptor could trigger processess that regilate different receptor
3. Receptor desensitization-
Decreased responsiveness of receptor with increased or chronic exposure to the agonists. Mostly occura in signaling membrane receptors.
4. Receptor internalization
Receptor mediated endocytosis process results in movement of receptors from plasma membrane to cell.
5. Receptor trafficking
Movement of receptors with in a neuron
6. Receptor down regulation
Characterized by decrease in total number of receptors in the cell by endocytosis.
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