Below is a diagram of the canonical Wnt signalling pathway. Numbers 1-7 refer to different molecules involved in the pathway. In addition to the main pathway components depicted above, outline some of the mechanisms that allow Wnt signalling to be ‘fine-tuned’.
Below is a diagram of the canonical Wnt signalling pathway. Numbers 1-7 refer to different molecules involved in the pathway. In addition to the main pathway components depicted above, outline some of the mechanisms that allow Wnt signalling to be ‘fine-tuned’.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
- Below is a diagram of the canonical Wnt signalling pathway. Numbers 1-7 refer to different molecules involved in the pathway. In addition to the main pathway components depicted above, outline some of the mechanisms that allow Wnt signalling to be ‘fine-tuned’.

Transcribed Image Text:Wnt
n
GSK3B
Golgi
apparatus
1
Endoplasmic
reticulum
LRP5/6
CDK14
Cyclin Y
CK1a
3
APC
l=
Wnt
B-catenin
TBP
DVL
GSK3B
YAP/TAZ
n
CK1a
PPP
B-catenin
B-catenin
Wnt
Wnt 2
ՈՄՆ
4
RNF43/
ZNRF3
BTrCP
BRG1 CBP/p300
B-catenin BCL9 Pygo
CK18
B-catenin
B-catenin
R-spondin
LGR5
Wnt target genes activated:
5......
6......
7......
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