Below is a diagram of the canonical Wnt signalling pathway. Numbers 1-7 refer to different molecules involved in the pathway. In addition to the main pathway components depicted above, outline some of the mechanisms that allow Wnt signalling to be ‘fine-tuned’.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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  1. Below is a diagram of the canonical Wnt signalling pathway. Numbers 1-7 refer to different molecules involved in the pathway. In addition to the main pathway components depicted above, outline some of the mechanisms that allow Wnt signalling to be ‘fine-tuned’.
Wnt
n
GSK3B
Golgi
apparatus
1
Endoplasmic
reticulum
LRP5/6
CDK14
Cyclin Y
CK1a
3
APC
l=
Wnt
B-catenin
TBP
DVL
GSK3B
YAP/TAZ
n
CK1a
PPP
B-catenin
B-catenin
Wnt
Wnt 2
ՈՄՆ
4
RNF43/
ZNRF3
BTrCP
BRG1 CBP/p300
B-catenin BCL9 Pygo
CK18
B-catenin
B-catenin
R-spondin
LGR5
Wnt target genes activated:
5......
6......
7......
Transcribed Image Text:Wnt n GSK3B Golgi apparatus 1 Endoplasmic reticulum LRP5/6 CDK14 Cyclin Y CK1a 3 APC l= Wnt B-catenin TBP DVL GSK3B YAP/TAZ n CK1a PPP B-catenin B-catenin Wnt Wnt 2 ՈՄՆ 4 RNF43/ ZNRF3 BTrCP BRG1 CBP/p300 B-catenin BCL9 Pygo CK18 B-catenin B-catenin R-spondin LGR5 Wnt target genes activated: 5...... 6...... 7......
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