TGF-B Receptor I (RI) phosphorylation of Smad2/3 does all of the following EXCEPT activate Smad2/3 binding to the Co-Smad Smad4 dissociate intramolecular binding of Smad2/3 MH1 and MH2 domains. RI phosphorylation of Smad2/3 does all of these things. release Smad2/3 from the nucleus into the cytoplasm unmask the Smad2/3 nuclear localization signal (NLS).
TGF-B Receptor I (RI) phosphorylation of Smad2/3 does all of the following EXCEPT activate Smad2/3 binding to the Co-Smad Smad4 dissociate intramolecular binding of Smad2/3 MH1 and MH2 domains. RI phosphorylation of Smad2/3 does all of these things. release Smad2/3 from the nucleus into the cytoplasm unmask the Smad2/3 nuclear localization signal (NLS).
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:**Educational Overview on TGF-β Receptor I (RI) Phosphorylation of Smad2/3**
The phosphorylation of Smad2/3 by TGF-β Receptor I (RI) involves several critical functions, except one. Here are the options associated with this biological process:
1. **Activates Smad2/3 Binding to Co-Smad Smad4**: This function involves Smad2/3 forming a complex with Smad4, essential for transmitting signals to the nucleus.
2. **Dissociates Intramolecular Binding of Smad2/3 MH1 and MH2 Domains**: This is the exception; TGF-β RI phosphorylation of Smad2/3 does not perform this function.
3. **RI Phosphorylation of Smad2/3 Performs All These Functions**: A general statement implying comprehensive functionality, which is incorrect in this context.
4. **Releases Smad2/3 from the Nucleus into the Cytoplasm**: Upon fulfilling its function, phosphorylated Smad2/3 can move back to the cytoplasm.
5. **Unmasks the Smad2/3 Nuclear Localization Signal (NLS)**: This action facilitates the transport of Smad2/3 into the nucleus.
Understanding these functions highlights the specificity and regulation involved in TGF-β signaling pathways.
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