The MARCH-1 E3-ubiquitin ligase is expressed in B cells, dendritic cells, and macrophages. The pathway regulated by MARCH-1 is targeted by some pathogens in an immune evasion strategy. In this strategy, the pathogens encode a protein that binds to MARCH-1 and inhibits its function. a protein that is induced by IL-10 in macrophages and dendritic cells. O a protein that induces degradation of MARCH-1. a protein that mimics MARCH-1 and functions similarly.

Q: Describe four mechanisms that result in the generation ofantigen receptor diversity.

A: Antibodies are the antigen-binding glycoproteins that are synthesized exclusively by B- cells and in…

Q: 12445 RD-Hom 4(167-277) A(194-277) A(97-138) A(97-167) 6 A(97-194) N595A 7890 A(619-723) HD 10…

A: A regulatory protein regulates the expression of a gene by binding with that gene through its DNA…

Q: Suppose you discover a drug that has potential antiviral effect against SARS-CoV2 so you tested its…

A: In microarray, the cDNA of both treated and untreated cells well put together in a well for a…

Q: An important mechanism for generating diversity in immunoglobulin light chain V-region sequences is…

A: The mechanism of gene recombination that occurs during B cell formation allows for the creation of…

Q: Identify the molecule that best matches each description. Each answer may be used once, more than…

A:

Q: If a mutation is introduced into I-KBα that inhibits it phosphorylation by the IKK complex, this…

A: Mutation in I-KBα that inhibits its phosphorylation by the IKK complex can prevent the translocation…

Q: BugRx is a new biotechnology company in Cambridge, Massachusetts, developing human monoclonal…

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Q: After a cell "clears" the G₁ restriction checkpoint, it can proceed into S phase. This S phase entry…

A: The cell cycle is regulated at following four crucial transitions: G1 to S S to G2 (very short) G2…

Q: A new class of cholesterol-lowering treatments that utilize small interfering RNAs (siRNAs) are…

A: siRNA, also known as short interfering RNA or silencing RNA, is a class of double-stranded RNA…

Q: Describe the mechanism by which cAMP receptorprotein (CRP), the regulatory protein for catabolite…

A: Operon is a functional unit of DNA that consists of cluster of genes under control of promoter.…

Q: Given that the the trp operon is a negative repressible operon what happens to the trp repressor in…

A: Introduction  The lac operon model is a classic example of gene regulation in prokaryotic cells. The…

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A: The light chains of an antibody can be classified as either kappa (κ) or lambda (λ) type based on…

Q: Quorum sensing controls the expression of virulencein many pathogenic bacteria. Usually, pathogens…

A: Quorum sensing is a type of signaling that works between bacteria present in a region. Bacteria…

Q: I need to make an antibody for the extracellular portion of the Notch receptor. I have made S35…

A: Hybridoma technology is used to produce a large number of monoclonal antibodies. Monoclonal…

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A: Cyclin and cyclin dependent kinases help in regulation of cell cycle, transcription, communication…

Q: What would happen to the regulation of the tryptophan operon in bacterial cells that express a…

A: In E. coli, all the 20 amino acids can be synthesized in vivo by the organism. The genes for the…

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Q: Proteins that are retained in the ER have a KDEL sequence at their C-terminus.  To test the idea…

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Q: Outline one mechanism used by activated mTOR to increase global translation in the cell.

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Q: Using baker's yeast it is possible to generate point mutations that destroy the kinase activity of…

A: Polyadenylation is a process of adding poly A tail to pre- mRNA.

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A: Zika virus has family - flaviviridae.  This virus spreds with the help of aedes mosquitoes. They…

Q: Arginine is one of the amino acids that serves as a building block for protein synthesis. Arginine…

A: Arginine is one of the amino acids that serves as a building block for protein synthesis. Arginine…

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A: The sequence TATA can be found in most promoters. This sequence binds RNA polymerase. The TATA box…

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A: Signaling pathway, is a series of chemical reactions that occur within a biological cell when…

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Q: Mutations in the IL2RG gene cause approximately 30 percent of severe combined immunodeficiency…

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Q: Match each of the following mechanisms with how it can change the levels of gene products--whether…

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A: RNA interference or Post-Transcriptional Gene Silencing is a simple and rapid method of silencing…

Q: Mice and humans with inactivating mutations in the gene encoding activation-induced cytidine…

A: IgM is described as a class of immunoglobulin. It displays its function by serving as the first line…

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Q: Which describes an enzymatic activity/biochemical function of importin-beta?     facilitate…

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Q: The protein NK2 is a transcriptional regulator that functions both as a repressor and activator. To…

A: A regulatory protein regulates the expression of a gene by binding with that gene through its DNA…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.