Outline the steps of receptor-mediated endocytosis, including the roles for each protein involved. Hint: if your answer does not include the protein dynamin, you are not providing enough detail. b. What will happen to Patched after it enters the cell via receptor-mediated endocytosis? Assume that Patched is not recycled back to the plasma membrane.

Human Anatomy & Physiology (11th Edition)
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When Hedgehog binds to Patched, this not only activates the signaling pathway but also
activates the receptor-mediated endocytosis of Patched, so there is less Patched on the plasma
membrane to inhibit Smoothened.

a. Outline the steps of receptor-mediated endocytosis, including the roles for each protein
involved. Hint: if your answer does not include the protein dynamin, you are not
providing enough detail.

b. What will happen to Patched after it enters the cell via receptor-mediated endocytosis?
Assume that Patched is not recycled back to the plasma membrane.

 

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