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Gleevec was described in Video 2.5 as a drug targeting the BCR-ABL fusion protein, an abnormal kinase encoded by an oncogene on the "Philadelphia chromosome" that is frequently found in chronic myelogenous leukemias. Gleevec is a kinase inhibitor that suppresses BCR-ABL fusion protein activity, and reduces tumor growth rate effectively in many CML patients with a Philadelphia chromosome. However, as with all mutation-targeting chemotherapeutic drugs, the efficacy of Gleevec declines over time in any given patient, and eventually it stops working to suppress tumor growth. Considering what you have learned about genetic changes underlying the formation and progression of tumors, propose an explanation for the decline in efficacy of Gleevec over time. Limit your answer to 1-2 sentences.

Gleevec was described in Video 2.5 as a drug targeting the BCR-ABL fusion protein, an abnormal kinase encoded by an oncogene on the "Philadelphia chromosome" that is frequently found in chronic myelogenous leukemias. Gleevec is a kinase inhibitor that suppresses BCR-ABL fusion protein activity, and reduces tumor growth rate effectively in many CML patients with a Philadelphia chromosome. However, as with all mutation-targeting chemotherapeutic drugs, the efficacy of Gleevec declines over time in any given patient, and eventually it stops working to suppress tumor growth. Considering what you have learned about genetic changes underlying the formation and progression of tumors, propose an explanation for the decline in efficacy of Gleevec over time. Limit your answer to 1-2 sentences.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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For tis question you don't need video 2.5 to answer it. Base on your understanding what will be the best answer to this 

Gleevec was described in Video 2.5 as a drug targeting the BCR-ABL fusion protein, an abnormal kinase encoded by an oncogene on the "Philadelphia chromosome" that is frequently found in chronic myelogenous leukemias. Gleevec is a kinase inhibitor that suppresses BCR-ABL fusion protein activity, and reduces tumor growth rate effectively in many CML patients with a Philadelphia chromosome. However, as with all mutation-targeting chemotherapeutic drugs, the efficacy of Gleevec declines over time in any given patient, and eventually it stops working to suppress tumor growth. Considering what you have learned about genetic changes underlying the formation and progression of tumors, propose an explanation for the decline in efficacy of Gleevec over time. Limit your answer to 1-2 sentences.
Transcribed Image Text:Gleevec was described in Video 2.5 as a drug targeting the BCR-ABL fusion protein, an abnormal kinase encoded by an oncogene on the "Philadelphia chromosome" that is frequently found in chronic myelogenous leukemias. Gleevec is a kinase inhibitor that suppresses BCR-ABL fusion protein activity, and reduces tumor growth rate effectively in many CML patients with a Philadelphia chromosome. However, as with all mutation-targeting chemotherapeutic drugs, the efficacy of Gleevec declines over time in any given patient, and eventually it stops working to suppress tumor growth. Considering what you have learned about genetic changes underlying the formation and progression of tumors, propose an explanation for the decline in efficacy of Gleevec over time. Limit your answer to 1-2 sentences.
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