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5.. A sample of cells has a total receptor concentration of 25 mM. Ninety percent of the receptors have bound ligand and the concentration of free ligand is 125 µM. Calculate the K for the receptor ligand interaction. (a) What is the AGº for binding for this interaction at 25°C?

5.. A sample of cells has a total receptor concentration of 25 mM. Ninety percent of the receptors have bound ligand and the concentration of free ligand is 125 µM. Calculate the K for the receptor ligand interaction. (a) What is the AGº for binding for this interaction at 25°C?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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5.. A sample of cells has a total receptor concentration of 25 mM. Ninety percent of the receptors have bound ligand and the concentration of free ligand is 125 µM. Calculate the Kp for the receptor ligand interaction. (a) What is the AGº for binding for this interaction at 25°C? (b) In a different system the total concentration of receptors in a sample is 20 mM. The concentration of free ligand is 5 mM and the Kp for the interaction is 10 mM. Calculate the fractional occupancy of the receptors. What is the AGº for binding for this interaction at 25°C?
Transcribed Image Text:5.. A sample of cells has a total receptor concentration of 25 mM. Ninety percent of the receptors have bound ligand and the concentration of free ligand is 125 µM. Calculate the Kp for the receptor ligand interaction. (a) What is the AGº for binding for this interaction at 25°C? (b) In a different system the total concentration of receptors in a sample is 20 mM. The concentration of free ligand is 5 mM and the Kp for the interaction is 10 mM. Calculate the fractional occupancy of the receptors. What is the AGº for binding for this interaction at 25°C?
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