32. The dose-response curves shown below represent responses of the metabotropic glutamate receptor in the presence of quisqualate agonist and another investigational ligand X. The top two curves are for the agonist quisqualate alone while the lower curves were obtained with the ligand X present. These curves can be reasonably interpreted as (select FALSE response): % Maximal efficacy relative to 10μm quisqualale 1201 100- 80- 60- 40- 20- O -11 -10 PEKI PO -8 W V Quisqualate [log M] -6 A. The ligand X is an allosteric antagonist. B. The ligand X is a competitive antagonist. C. The concentration of the ligand X is higher for the bottom (open circles) than the middle (inverted triangles) curve. D. The ligand X decreases the efficacy of quisqualate agonist. E. The ligand X does not change the potency of quisqualate (or just slightly).
32. The dose-response curves shown below represent responses of the metabotropic glutamate receptor in the presence of quisqualate agonist and another investigational ligand X. The top two curves are for the agonist quisqualate alone while the lower curves were obtained with the ligand X present. These curves can be reasonably interpreted as (select FALSE response): % Maximal efficacy relative to 10μm quisqualale 1201 100- 80- 60- 40- 20- O -11 -10 PEKI PO -8 W V Quisqualate [log M] -6 A. The ligand X is an allosteric antagonist. B. The ligand X is a competitive antagonist. C. The concentration of the ligand X is higher for the bottom (open circles) than the middle (inverted triangles) curve. D. The ligand X decreases the efficacy of quisqualate agonist. E. The ligand X does not change the potency of quisqualate (or just slightly).
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![B. Compound B is a partial agonist.
C. The studied GPCR is a constitutively active receptor.
D. Compound C shows no effect, hence it is an antagonist.
E. Compounds D are inverse agonists with varying degree of efficacy.
32. The dose-response curves shown below represent responses of the metabotropic glutamate
receptor in the presence of quisqualate agonist and another investigational ligand X. The
top two curves are for the agonist quisqualate alone while the lower curves were obtained
with the ligand X present. These curves can be reasonably interpreted as (select FALSE
response):
% Maximal efficacy relative
to 10μm quisqualale
120
100-
80-
60-
40-
20-
0
-11 -10
-8
V
-7
Quisqualate [log M]
un agonists.
Z
F
-6
-5
A. The ligand X is an allosteric antagonist.
B. The ligand X is a competitive antagonist.
C. The concentration of the ligand X is higher for the bottom (open circles) than the middle
(inverted triangles) curve.
D. The ligand X decreases the efficacy of quisqualate agonist.
E. The ligand X does not change the potency of quisqualate (or just slightly).](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F56cd83b8-1145-4314-8c0f-0f1380afd7fa%2F73622913-d27f-4a7a-b16e-abbca920689c%2F0y7976e_processed.jpeg&w=3840&q=75)
Transcribed Image Text:B. Compound B is a partial agonist.
C. The studied GPCR is a constitutively active receptor.
D. Compound C shows no effect, hence it is an antagonist.
E. Compounds D are inverse agonists with varying degree of efficacy.
32. The dose-response curves shown below represent responses of the metabotropic glutamate
receptor in the presence of quisqualate agonist and another investigational ligand X. The
top two curves are for the agonist quisqualate alone while the lower curves were obtained
with the ligand X present. These curves can be reasonably interpreted as (select FALSE
response):
% Maximal efficacy relative
to 10μm quisqualale
120
100-
80-
60-
40-
20-
0
-11 -10
-8
V
-7
Quisqualate [log M]
un agonists.
Z
F
-6
-5
A. The ligand X is an allosteric antagonist.
B. The ligand X is a competitive antagonist.
C. The concentration of the ligand X is higher for the bottom (open circles) than the middle
(inverted triangles) curve.
D. The ligand X decreases the efficacy of quisqualate agonist.
E. The ligand X does not change the potency of quisqualate (or just slightly).
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