Homework Help is Here – Start Your Trial Now!
Science
Biology
A O 1 2 3 456 7 8 9 CG site number 1 2 3 4 5 6 7 8 9 CG site number *p<0.05 ##p<0.01 The viable yellow allele has provided a valuable tool for investigating the impact of diet on epigenetic regulation of obesity, since the Agouti gene also has a (poorly understood) role in body weight regulation. A study published in 2007 (Dolinoy et al., Proc. Nat. Acad. Sci. USA 104:13056-13061) investigated effects of BPA (bisphenol A, a chemical used in the manufacturing of plastics, which is associated with elevated body weight and other adverse health outcomes in humans) on methylation of the IAP insertion in the viable yellow allele. The figure above shows that mice with the viable yellow allele whose mothers were fed a BPA-containing diet during pregnancy had significantly lower levels of methylation at multiple CG dinucleotides within IAP compared to mice whose mothers were fed a control diet. What difference in fur color would you expect to see between mice in the two groups above (mice whose mothers were fed control diet vs. BPA diet)? Provide one sentence of rationale for your answer based on what you know about the impact of CG methylation on gene expression, including a clear prediction regarding the expression level of the Agouti gene in the two groups.

A O 1 2 3 456 7 8 9 CG site number 1 2 3 4 5 6 7 8 9 CG site number *p<0.05 ##p<0.01 The viable yellow allele has provided a valuable tool for investigating the impact of diet on epigenetic regulation of obesity, since the Agouti gene also has a (poorly understood) role in body weight regulation. A study published in 2007 (Dolinoy et al., Proc. Nat. Acad. Sci. USA 104:13056-13061) investigated effects of BPA (bisphenol A, a chemical used in the manufacturing of plastics, which is associated with elevated body weight and other adverse health outcomes in humans) on methylation of the IAP insertion in the viable yellow allele. The figure above shows that mice with the viable yellow allele whose mothers were fed a BPA-containing diet during pregnancy had significantly lower levels of methylation at multiple CG dinucleotides within IAP compared to mice whose mothers were fed a control diet. What difference in fur color would you expect to see between mice in the two groups above (mice whose mothers were fed control diet vs. BPA diet)? Provide one sentence of rationale for your answer based on what you know about the impact of CG methylation on gene expression, including a clear prediction regarding the expression level of the Agouti gene in the two groups.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question

23

AVY Site Specific Methylation (%) 100 75 50 25 0 1 2 Control Diet TII 3 4 5 6 CG site number 7 8 9 X BPA Diet ## * * T 1 2 3 4 5 67 8 CG site number *p<0.05 ##p<0.01 9 The viable yellow allele has provided a valuable tool for investigating the impact of diet on epigenetic regulation of obesity, since the Agouti gene also has a (poorly understood) role in body weight regulation. A study published in 2007 (Dolinoy al., Proc. Nat. Acad. Sci. USA 104:13056-13061) investigated effects of BPA (bisphenol A, a chemical used in the manufacturing of plastics, which is associated with elevated body weight and other adverse health outcomes in humans) on methylation of the IAP insertion in the viable yellow allele. The figure above shows that mice with the viable yellow allele whose mothers were fed a BPA-containing diet during pregnancy had significantly lower levels of methylation at multiple CG dinucleotides within IAP compared to mice whose mothers were fed a control diet. What difference in fur color would you expect to see between mice in the two groups above (mice whose mothers were fed control diet vs. BPA diet)? Provide one sentence of rationale for your answer based on what you know about the
Transcribed Image Text:AVY Site Specific Methylation (%) 100 75 50 25 0 1 2 Control Diet TII 3 4 5 6 CG site number 7 8 9 X BPA Diet ## * * T 1 2 3 4 5 67 8 CG site number *p<0.05 ##p<0.01 9 The viable yellow allele has provided a valuable tool for investigating the impact of diet on epigenetic regulation of obesity, since the Agouti gene also has a (poorly understood) role in body weight regulation. A study published in 2007 (Dolinoy al., Proc. Nat. Acad. Sci. USA 104:13056-13061) investigated effects of BPA (bisphenol A, a chemical used in the manufacturing of plastics, which is associated with elevated body weight and other adverse health outcomes in humans) on methylation of the IAP insertion in the viable yellow allele. The figure above shows that mice with the viable yellow allele whose mothers were fed a BPA-containing diet during pregnancy had significantly lower levels of methylation at multiple CG dinucleotides within IAP compared to mice whose mothers were fed a control diet. What difference in fur color would you expect to see between mice in the two groups above (mice whose mothers were fed control diet vs. BPA diet)? Provide one sentence of rationale for your answer based on what you know about the
AV 0 1 2 3 4 5 6 7 8 CG site number 9 1 2 3 4 5 67 8 9 CG site number *p<0.05 ## p<0.01 The viable yellow allele has provided a valuable tool for investigating the impact of diet on epigenetic regulation of obesity, since the Agouti gene also has a (poorly understood) role in body weight regulation. A study published in 2007 (Dolinoy et al., Proc. Nat. Acad. Sci. USA 104:13056-13061) investigated effects of BPA (bisphenol A, a chemical used in the manufacturing of plastics, which is associated with elevated body weight and other adverse health outcomes in humans) on methylation of the IAP insertion in the viable yellow allele. The figure above shows that mice with the viable yellow allele whose mothers were fed a BPA-containing diet during pregnancy had significantly lower levels of methylation at multiple CG dinucleotides within IAP compared to mice whose mothers were fed a control diet. What difference in fur color would you expect to see between mice in the two groups above (mice whose mothers were fed control diet vs. BPA diet)? Provide one sentence of rationale for your answer based on what you know about the impact of CG methylation on gene expression, including a clear prediction regarding the expression level of the Agouti gene in the two groups.
Transcribed Image Text:AV 0 1 2 3 4 5 6 7 8 CG site number 9 1 2 3 4 5 67 8 9 CG site number *p<0.05 ## p<0.01 The viable yellow allele has provided a valuable tool for investigating the impact of diet on epigenetic regulation of obesity, since the Agouti gene also has a (poorly understood) role in body weight regulation. A study published in 2007 (Dolinoy et al., Proc. Nat. Acad. Sci. USA 104:13056-13061) investigated effects of BPA (bisphenol A, a chemical used in the manufacturing of plastics, which is associated with elevated body weight and other adverse health outcomes in humans) on methylation of the IAP insertion in the viable yellow allele. The figure above shows that mice with the viable yellow allele whose mothers were fed a BPA-containing diet during pregnancy had significantly lower levels of methylation at multiple CG dinucleotides within IAP compared to mice whose mothers were fed a control diet. What difference in fur color would you expect to see between mice in the two groups above (mice whose mothers were fed control diet vs. BPA diet)? Provide one sentence of rationale for your answer based on what you know about the impact of CG methylation on gene expression, including a clear prediction regarding the expression level of the Agouti gene in the two groups.
Expert Solution
steps

Step by step

Solved in 3 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Genomic studies
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS