Answered: Hyper-IgE syndrome, also known as Job’s…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Hyper-IgE syndrome, also known as Job’s syndrome, is an immunodeficiency disease resulting from the lack of function of a single gene (gene ‘X’). To investigate the immune mechanism impaired in these patients, a mouse model of this gene deficiency was generated. Conditional knockout mouse lines were generated in which gene X was knocked out in either the T cells, the B cells, or the myeloid cells of the mouse. For each conditional knockout line, mice were challenged with Candida albicans, and the ability to clear the infection was assessed. In mice, infection of the oral cavity with Candida albicans has been shown to be a valid model for mucosal Candida albicans infections in humans. After infection, the response was assessed by measuring fungal burden (CFU/g tissue) on the tongue. The resulting data are shown in figure below. Based on these data, what is the most likely immune function impaired in the Gene X-deficient patients?

CFU/g tissue 10
105
10*
103
102
10
15
20
Days post infection
Wild-type
B cell-deleted
T cell-deleted
Myeloid-deleted

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