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Which of these methods is appropriate for making a mouse model for cystic fibrosis, which is a recessive disease caused by various loss-of-function mutations in the CFTR gene? Select all that apply. CFTR gene inactivated by a marker gene is introduced to embryonic stem cells CRISPR that knocks in a mutant copy of the gene to a mouse genome Pronuclear injection of a mutant copy of the gene to a mouse zygote RNAI that knocks down the wild-type gene expression in a mouse genome CRISPR that knocks out the wild-type gene in a mouse genome O O O 0 0

Which of these methods is appropriate for making a mouse model for cystic fibrosis, which is a recessive disease caused by various loss-of-function mutations in the CFTR gene? Select all that apply. CFTR gene inactivated by a marker gene is introduced to embryonic stem cells CRISPR that knocks in a mutant copy of the gene to a mouse genome Pronuclear injection of a mutant copy of the gene to a mouse zygote RNAI that knocks down the wild-type gene expression in a mouse genome CRISPR that knocks out the wild-type gene in a mouse genome O O O 0 0

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Which of these methods is appropriate for making a mouse model for cystic fibrosis, which is a recessive disease caused by various loss-of-function mutations in the CFTR gene? Select all that apply. CFTR gene inactivated by a marker gene is introduced to embryonic stem cells CRISPR that knocks in a mutant copy of the gene to a mouse genome Pronuclear injection of a mutant copy of the gene to a mouse zygote RNAI that knocks down the wild-type gene expression in a mouse genome CRISPR that knocks out the wild-type gene in a mouse genome
Transcribed Image Text:Which of these methods is appropriate for making a mouse model for cystic fibrosis, which is a recessive disease caused by various loss-of-function mutations in the CFTR gene? Select all that apply. CFTR gene inactivated by a marker gene is introduced to embryonic stem cells CRISPR that knocks in a mutant copy of the gene to a mouse genome Pronuclear injection of a mutant copy of the gene to a mouse zygote RNAI that knocks down the wild-type gene expression in a mouse genome CRISPR that knocks out the wild-type gene in a mouse genome
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